Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (TIR:1AD)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7nak
Q-score: 0.522
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T
Mol Cell (2022) 82 pp. 1643- [ Pubmed: 35334231 DOI: doi:10.1016/j.molcel.2022.03.007 ]
- [[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{r},3~{s},4~{r},5~{r})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (797 Da, Ligand)
- Nad(+) hydrolase sarm1 (76 kDa, Protein from Homo sapiens)
- Human sarm1 in complex with nmn and 1ad (Complex from Homo sapiens)
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7nal
Q-score: 0.501
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T
Mol Cell (2022) 82 pp. 1643- [ Pubmed: 35334231 DOI: doi:10.1016/j.molcel.2022.03.007 ]
- Beta-nicotinamide ribose monophosphate (335 Da, Ligand)
- Nad(+) hydrolase sarm1 (76 kDa, Protein from Homo sapiens)
- Human sarm1 in complex with nmn and 1ad (Complex from Homo sapiens)
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (SAM-TIR:1AD)
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T
Mol Cell (2022) 82 pp. 1643-1659.e10 [ Pubmed: 35334231 DOI: doi:10.1016/j.molcel.2022.03.007 ]
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7knq
Q-score: 0.454
Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2023151118 Pubmed: 33468661 ]
- Octameric form of sarm1 (Complex from Homo sapiens)
- Nad(+) hydrolase sarm1 (79 kDa, Protein from Homo sapiens)
Cryo-EM structure of ligand-free Human SARM1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ld0
Q-score: 0.416
Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T
Neuron (2021) 109 pp. 1118- [ DOI: doi:10.1016/j.neuron.2021.02.009 Pubmed: 33657413 ]
- Homo-octameric sarm1 (Complex from Homo sapiens)
- Nad(+) hydrolase sarm1 (76 kDa, Protein from Homo sapiens)