Cryo-EM structure of human ER membrane protein complex in lipid nanodiscs
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 7ado
Q-score: 0.458
Miller-Vedam LE, Brauning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
eLife (2020) 9 [ DOI: doi:10.7554/eLife.62611 Pubmed: 33236988 ]
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (27 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
- Membrane magnesium transporter 1 (15 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Unassigned helix (1 kDa, Protein from Homo sapiens)
- Human endoplasmic reticulum membrane protein complex (emc) in popc nanodiscs (300 kDa, Complex from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human ER membrane protein complex in GDN detergent
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7adp
Q-score: 0.43
Miller-Vedam LE, Brauning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
eLife (2020) 9 [ DOI: doi:10.7554/eLife.62611 Pubmed: 33236988 ]
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (27 kDa, Protein from Homo sapiens)
- Membrane magnesium transporter 1 (15 kDa, Protein from Homo sapiens)
- Human endoplasmic reticulum membrane protein complex (emc) in popc nanodiscs (300 kDa, Complex from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7kra
Q-score: 0.474
Miller-Vedam LE, Brauning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
eLife (2020) 9 [ DOI: doi:10.7554/eLife.62611 Pubmed: 33236988 ]
- Er membrane protein complex subunit 6 (12 kDa, Protein from Saccharomyces cerevisiae)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab dh4 (Complex from Homo sapiens)
- S. cerevisiae endoplasmic reticulum membrane protein complex (emc) bound to fab dh4 in yeast total extract lipid nanodiscs (Complex)
- Er membrane protein complex subunit 5 (20 kDa, Protein from Saccharomyces cerevisiae)
- Er membrane protein complex subunit 4 (21 kDa, Protein from Saccharomyces cerevisiae)
- Endoplasmic reticulum membrane protein complex subunit 10 (22 kDa, Protein from Saccharomyces cerevisiae)
- Er membrane protein complex subunit 2 (33 kDa, Protein from Saccharomyces cerevisiae)
- Fab dh4 heavy chain (26 kDa, Protein from Homo sapiens)
- [(2~{r})-1-octanoyloxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propan-2-yl] nonanoate (524 Da, Ligand)
- Er membrane protein complex subunit 1 (87 kDa, Protein from Saccharomyces cerevisiae)
- Er membrane protein complex subunit 3 (28 kDa, Protein from Saccharomyces cerevisiae)
- Protein sop4 (26 kDa, Protein from Saccharomyces cerevisiae)
- Unassigned helix (2 kDa, Protein from Saccharomyces cerevisiae)
- Endoplasmic reticulum membrane protein complex (Complex from Saccharomyces cerevisiae)
- Fab dh4 light chain (25 kDa, Protein from Homo sapiens)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7ktx
Q-score: 0.287
Miller-Vedam LE, Brauning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
eLife (2020) 9 [ DOI: doi:10.7554/eLife.62611 Pubmed: 33236988 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab dh4 (Complex from Homo sapiens)
- S. cerevisiae endoplasmic reticulum membrane protein complex (emc) bound to fab in ddm detergent (Complex)
- Er membrane protein complex subunit 5 (20 kDa, Protein from Saccharomyces cerevisiae BY4743)
- Fab dh4 light chain (25 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Saccharomyces cerevisiae BY4743)
- Er membrane protein complex subunit 1 (87 kDa, Protein from Saccharomyces cerevisiae BY4743)
- Endoplasmic reticulum membrane protein complex subunit 10 (22 kDa, Protein from Saccharomyces cerevisiae BY4743)
- Fab dh4 heavy chain (26 kDa, Protein from Homo sapiens)
- Protein sop4 (26 kDa, Protein from Saccharomyces cerevisiae BY4743)
- Unassigned helix (2 kDa, Protein from Saccharomyces cerevisiae BY4743)
- Er membrane protein complex subunit 4 (21 kDa, Protein from Saccharomyces cerevisiae BY4743)
- Er membrane protein complex subunit 3 (28 kDa, Protein from Saccharomyces cerevisiae BY4743)
- Endoplasmic reticulum membrane protein complex (Complex from Saccharomyces cerevisiae BY4743)
- Er membrane protein complex subunit 2 (33 kDa, Protein from Saccharomyces cerevisiae BY4743)
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 6o81
Q-score: 0.324
Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A
Science (2019) 364 pp. 491-495 [ DOI: doi:10.1126/science.aaw2922 Pubmed: 31048491 ]
- Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
- Eif2b bound to eif2 (Complex from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 3 (51 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif2 beta-subunit (1 kDa, Protein from Homo sapiens)
- 2-(4-chloranylphenoxy)-~{n}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide (451 Da, Ligand)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 6o85
Q-score: 0.359
Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A
Science (2019) 364 pp. 491-495 [ DOI: doi:10.1126/science.aaw2922 Pubmed: 31048491 ]
- Eukaryotic translation initiation factor 2 subunit beta (1 kDa, Protein from Homo sapiens)
- 2-(4-chloranylphenoxy)-~{n}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide (451 Da, Ligand)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Eif2 bound to eif2b (Cellular component from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 3 (51 kDa, Protein from Homo sapiens)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 6o9z
Q-score: 0.441
Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A
Science (2019) 364 pp. 491-495 [ DOI: doi:10.1126/science.aaw2922 Pubmed: 31048491 ]
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 1 (37 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Eif2 alpha-p bound to eif2b (Cellular component from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6caj
Q-score: 0.453
Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P
Science (2018) 359 [ DOI: doi:10.1126/science.aaq0939 Pubmed: 29599213 ]
- Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b decamer (Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- 2-(4-chloranylphenoxy)-~{n}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide (451 Da, Ligand)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens
Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P
Science (2018) 359 [ Pubmed: 29599213 DOI: doi:10.1126/science.aaq0939 ]
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens
Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P
Science (2018) 359 [ DOI: doi:10.1126/science.aaq0939 Pubmed: 29599213 ]