Ectodomain of full-length wild-type KIT-SCF dimers
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8dfm
Q-score: 0.458
Krimmer SG, Bertoletti N, Suzuki Y, Katic L, Mohanty J, Shu S, Lee S, Lax I, Mi W, Schlessinger J
PNAS (2023) 120 pp. e2300054120-e2300054120 [ DOI: doi:10.1073/pnas.2300054120 Pubmed: 36943885 ]
- Soluble kit ligand (16 kDa, Protein from Homo sapiens)
- Isoform 2 of mast/stem cell growth factor receptor kit (110 kDa, Protein from Homo sapiens)
- Full-length wild-type kit-scf dimers reconstituted in amphipol (250 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Ectodomain of full-length KIT(DupA502,Y503)-SCF dimers
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8dfp
Q-score: 0.496
Krimmer SG, Bertoletti N, Suzuki Y, Katic L, Mohanty J, Shu S, Lee S, Lax I, Mi W, Schlessinger J
PNAS (2023) 120 pp. e2300054120-e2300054120 [ DOI: doi:10.1073/pnas.2300054120 Pubmed: 36943885 ]
- Isoform 2 of mast/stem cell growth factor receptor kit (110 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Soluble kit ligand (14 kDa, Protein from Homo sapiens)
- Full-length kit(dupa502,y503)-scf dimers reconstituted in amphipol (250 kDa, Complex from Homo sapiens)
Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 8dfq
Q-score: 0.422
Krimmer SG, Bertoletti N, Suzuki Y, Katic L, Mohanty J, Shu S, Lee S, Lax I, Mi W, Schlessinger J
PNAS (2023) 120 pp. e2300054120-e2300054120 [ DOI: doi:10.1073/pnas.2300054120 Pubmed: 36943885 ]
- Isoform 2 of mast/stem cell growth factor receptor kit (110 kDa, Protein from Homo sapiens)
- Soluble kit ligand (16 kDa, Protein from Homo sapiens)
- Full-length kit(t417i,delta418-419)-scf dimers reconstituted in amphipol (250 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Full-length KIT(T417I,delta418-419) dimers
Krimmer SG, Bertoletti N, Suzuki Y, Katic L, Mohanty J, Shu S, Lee S, Lax I, Mi W, Schlessinger J
PNAS (2023) 120 pp. e2300054120-e2300054120 [ DOI: doi:10.1073/pnas.2300054120 Pubmed: 36943885 ]
Full-length KIT(T417I,delta418-419) dimers
Krimmer SG, Bertoletti N, Suzuki Y, Katic L, Mohanty J, Shu S, Lee S, Lax I, Mi W, Schlessinger J
PNAS (2023) 120 pp. e2300054120-e2300054120 [ DOI: doi:10.1073/pnas.2300054120 Pubmed: 36943885 ]
Reshetnyak AV, Rossi P, Myasnikov AG, Sowaileh M, Mohanty J, Nourse A, Miller DJ, Lax I, Schlessinger J, Kalodimos CG
Nature (2021) 7887 pp. 153-157 [ DOI: 10.1038/s41586-021-04140-8 Pubmed: 34819673 ]
Image sets:
Resolution: 2.27 Å
EM Method: Single-particle
Fitted PDBs: 7n00
Q-score: 0.524
Reshetnyak AV, Rossi P, Myasnikov AG, Sowaileh M, Mohanty J, Nourse A, Miller DJ, Lax I, Schlessinger J, Kalodimos CG
Nature (2021) 600 pp. 153-157 [ DOI: doi:10.1038/s41586-021-04140-8 Pubmed: 34819673 ]
- Alk and ltk ligand 2 (14 kDa, Protein from Homo sapiens)
- Hetero-tetrameric complex of anaplastic lymphoma kinase (alk) with augmentor alpha (108 MDa, Complex from Homo sapiens)
- Alk tyrosine kinase receptor (39 kDa, Protein from Homo sapiens)