Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 2)
Resolution: 2.9 Å
EM Method: Helical reconstruction
Fitted PDBs: 9fof
Q-score: 0.383
Arseni D, Nonaka T, Jacobsen MH, Murzin AG, Cracco L, Peak-Chew SY, Garringer HJ, Kawakami I, Suzuki H, Onaya M, Saito Y, Murayama S, Geula C, Vidal R, Newell KL, Mesulam M, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
bioRxiv (2024) [ Pubmed: 38979278 DOI: doi:10.1101/2024.06.25.600403 ]
Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C (variant 1)
Resolution: 2.75 Å
EM Method: Helical reconstruction
Fitted PDBs: 9for
Q-score: 0.671
Arseni D, Nonaka T, Jacobsen MH, Murzin AG, Cracco L, Peak-Chew SY, Garringer HJ, Kawakami I, Suzuki H, Onaya M, Saito Y, Murayama S, Geula C, Vidal R, Newell KL, Mesulam M, Ghetti B, Hasegawa M, Ryskeldi-Falcon B
bioRxiv (2024) [ Pubmed: 38979278 DOI: doi:10.1101/2024.06.25.600403 ]
Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M
Nature (2022) 610 pp. 791-795 [ Pubmed: 36108674 DOI: 10.1038/s41586-022-05319-3 ]
Image sets:
Resolution: 2.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8a9l
Q-score: 0.653
Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M
Nature (2022) 610 pp. 791-795 [ DOI: doi:10.1038/s41586-022-05319-3 Pubmed: 36108674 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Unknown fragment (783 Da, Protein from Homo sapiens)
- Alpha-synuclein filaments extracted from the human brain with pd, pdd, and dlb (Tissue from Homo sapiens)
- Unknown fragment (627 Da, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM reconstruction of TMEM106B fold I-d filaments from case 18 with multiple system atrophy
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lövestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: 10.1038/s41586-022-04650-z Pubmed: 35344985 ]
Image sets:
TMEM106B filaments with Fold I from Alzheimer's disease (case 1)
Resolution: 2.64 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qvc
Q-score: 0.617
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from Homo sapiens)
TMEM106B filaments with Fold I-d from Multiple system atrophy (case 18)
Resolution: 3.64 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qvf
Q-score: 0.469
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from Homo sapiens)
TMEM106B filaments with Fold IIa from Multiple system atrophy (case 19)
Resolution: 3.38 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qwg
Q-score: 0.53
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from Homo sapiens)
TMEM106B filaments with Fold IIb from Multiple system atrophy (case 19)
Resolution: 3.47 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qwl
Q-score: 0.513
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from Homo sapiens)
TMEM106B filaments with Fold III from Multiple system atrophy (case 17)
Resolution: 2.76 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qwm
Q-score: 0.671
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from Homo sapiens)