Cryo-EM structure of SH-SY5Y seeded with filaments from Alzheimer's Disease
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ore
Q-score: 0.593
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ DOI: doi:10.1002/2211-5463.13657 Pubmed: 37337995 ]
- Tau amyloid filaments (Cell from Homo sapiens)
- Microtubule-associated protein tau (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8orf
Q-score: 0.601
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ DOI: doi:10.1002/2211-5463.13657 Pubmed: 37337995 ]
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
- Tau amyloid filaments (Cell from Homo sapiens)
Cryo-EM structure of SH-SY5Y seeded with filaments from corticobasal degeneration extracts (Type II)
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8org
Q-score: 0.606
Tarutani A, Lovestam S, Zhang X, Kotecha A, Robinson AC, Mann DMA, Saito Y, Murayama S, Tomita T, Goedert M, Scheres SHW, Hasegawa M
FEBS Open Bio (2023) 13 pp. 1394-1404 [ DOI: doi:10.1002/2211-5463.13657 Pubmed: 37337995 ]
- Microtubule-associated protein tau (43 kDa, Protein from Homo sapiens)
- Tau amyloid filaments (Cell from Homo sapiens)
Cryo-EM of Multiple System Atrophy seeded assembly of alpha-synuclein filaments
Lövestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres S
FEBS Open Bio (2021) [ Pubmed: 33548114 DOI: 10.1002/2211-5463.13110 ]
Image sets:
- Type 1A particles after Bayesian polishing
- Type 2AB particles after Bayesian polishing
- Unaligned movies of alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 5
- Type 1B particles after Bayesian polishing
- Type 3 particles after Bayesian polishing
- Unaligned movies of alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2
- Type 2A particles after Bayesian polishing
- Unaligned movies of alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1
- Type 2B particles after Bayesian polishing
Resolution: 3.47 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nca
Q-score: 0.559
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 3.43 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ncg
Q-score: 0.494
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 3.84 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nch
Q-score: 0.244
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 3.55 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nci
Q-score: 0.377
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 4.23 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ncj
Q-score: 0.176
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)
Resolution: 3.18 Å
EM Method: Helical reconstruction
Fitted PDBs: 7nck
Q-score: 0.498
Lovestam S, Schweighauser M, Matsubara T, Murayama S, Tomita T, Ando T, Hasegawa K, Yoshida M, Tarutani A, Hasegawa M, Goedert M, Scheres SHW
FEBS Open Bio (2021) 11 pp. 999-1013 [ DOI: doi:10.1002/2211-5463.13110 Pubmed: 33548114 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha synuclein filament (Complex from Homo sapiens)