CryoEM structure of PN45545 TCR-CD3 complex
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8es7
Q-score: 0.531
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45545 tcr beta chain (35 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Pn45545 tcr-cd3 complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pn45545 tcr alpha chain (30 kDa, Protein from Homo sapiens)
CryoEM structure of PN45545 TCR-CD3 in complex with HLA-A2 MAGEA4 (230-239)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8es8
Q-score: 0.537
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- Pn45545 tcr-cd3 complex bound to hla-a2 magea4 (230-239) with anti-beta-2-microglobulin fab (Complex from Homo sapiens)
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 (1 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45545 tcr beta chain (35 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- Pn45545 tcr alpha chain (30 kDa, Protein from Homo sapiens)
CryoEM structure of PN45428 TCR-CD3 in complex with HLA-A2 MAGEA4
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8es9
Q-score: 0.475
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Pn45428 tcr beta chain (35 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 (1 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45428 tcr-cd3 complex bound to hla-a2 magea4 (230-239) in the presence of 2m2 fab (Complex from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pn45428 tcr alpha chain (30 kDa, Protein from Homo sapiens)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
CryoEM structure of HLA-A2 bound to MAGEA4 (230-239) peptide
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8esa
Q-score: 0.527
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
CryoEM structure of HLA-A2 bound to MAGEA8 (232-241) peptide
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8esb
Q-score: 0.551
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6xdg
Q-score: 0.348
Hansen J, Baum A, Pascal KE, Russo V, Giordano S, Wloga E, Fulton BO, Yan Y, Koon K, Patel K, Chung KM, Hermann A, Ullman E, Cruz J, Rafique A, Huang T, Fairhurst J, Libertiny C, Malbec M, Lee WY, Welsh R, Farr G, Pennington S, Deshpande D, Cheng J, Watty A, Bouffard P, Babb R, Levenkova N, Chen C, Zhang B, Romero Hernandez A, Saotome K, Zhou Y, Franklin M, Sivapalasingam S, Lye DC, Weston S, Logue J, Haupt R, Frieman M, Chen G, Olson W, Murphy AJ, Stahl N, Yancopoulos GD, Kyratsous CA
Science (2020) 369 pp. 1010-1014 [ Pubmed: 32540901 DOI: doi:10.1126/science.abd0827 ]
- Spike protein s1 (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Complex of sars-cov-2 spike protein receptor binding domain with fab fragments of two neutralizing antibodies (Complex)
- Regn10933 antibody fab fragment (Complex from Homo sapiens)
- Regn10933 antibody fab fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Regn10987 antibody fab fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Regn10987 antibody fab fragment (Complex from Homo sapiens)
- Regn10933 antibody fab fragment light chain (23 kDa, Protein from Homo sapiens)
- Regn10987 antibody fab fragment light chain (22 kDa, Protein from Homo sapiens)
- Spike protein receptor binding domain (Complex from Severe acute respiratory syndrome coronavirus 2)