Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8tg9
Q-score: 0.495
Dunn ME, Kithcart A, Kim JH, Ho AJ, Franklin MC, Romero Hernandez A, de Hoon J, Botermans W, Meyer J, Jin X, Zhang D, Torello J, Jasewicz D, Kamat V, Garnova E, Liu N, Rosconi M, Pan H, Karnik S, Burczynski ME, Zheng W, Rafique A, Nielsen JB, De T, Verweij N, Pandit A, Locke A, Chalasani N, Melander O, Schwantes-An TH, Baras A, Lotta LA, Musser BJ, Mastaitis J, Devalaraja-Narashimha KB, Rankin AJ, Huang T, Herman G, Olson W, Murphy AJ, Yancopoulos GD, Olenchock BA, Morton L
Nature (2024) 633 pp. 654-661 [ Pubmed: 39261724 DOI: doi:10.1038/s41586-024-07903-1 ]
- Regn5381 fab heavy chain (24 kDa, Protein from Mus musculus)
- Regn5381 fab light chain (23 kDa, Protein from Mus musculus)
- Active complex of npr1 ectodomain, anp, and regn5381 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atrial natriuretic peptide (3 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (52 kDa, Protein from Homo sapiens)
CryoEM structure of PN45545 TCR-CD3 complex
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8es7
Q-score: 0.531
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45545 tcr beta chain (35 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Pn45545 tcr-cd3 complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pn45545 tcr alpha chain (30 kDa, Protein from Homo sapiens)
CryoEM structure of PN45545 TCR-CD3 in complex with HLA-A2 MAGEA4 (230-239)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8es8
Q-score: 0.537
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- Pn45545 tcr-cd3 complex bound to hla-a2 magea4 (230-239) with anti-beta-2-microglobulin fab (Complex from Homo sapiens)
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 (1 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45545 tcr beta chain (35 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- Pn45545 tcr alpha chain (30 kDa, Protein from Homo sapiens)
CryoEM structure of PN45428 TCR-CD3 in complex with HLA-A2 MAGEA4
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8es9
Q-score: 0.475
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Pn45428 tcr beta chain (35 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 (1 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45428 tcr-cd3 complex bound to hla-a2 magea4 (230-239) in the presence of 2m2 fab (Complex from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pn45428 tcr alpha chain (30 kDa, Protein from Homo sapiens)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
Cryo-EM map of human LIF signaling complex with full extracellular domains
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8d6a
Q-score: 0.357
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human lif in complex with gp130 and lifr (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor (19 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8d74
Q-score: 0.432
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (35 kDa, Protein from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Human cntf in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
Cryo-EM structure of human CLCF1 in complex with CRLF1 and CNTFR alpha
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8d7h
Q-score: 0.394
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Ciliary neurotrophic factor receptor subunit alpha (39 kDa, Protein from Homo sapiens)
- Cytokine receptor-like factor 1 (44 kDa, Protein from Homo sapiens)
- Human clcf1 in complex with in complex with crlf1 and cntfr alpha (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
Cryo-EM map of human CLCF1 signaling complex with full extracellular domains
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8d7r
Q-score: 0.268
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Human clcf1 in complex with cntfr alpha, gp130, and lifr (Complex from Homo sapiens)
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cardiotrophin-like cytokine factor 1 (23 kDa, Protein from Homo sapiens)
- Ciliary neurotrophic factor receptor subunit alpha (36 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Cryo-EM map of detergent-solubilized human IL-6 signaling complex with full extracellular domains
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8d82
Q-score: 0.392
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ Pubmed: 36930708 DOI: doi:10.1126/sciadv.ade4395 ]
- Interleukin-6 receptor subunit beta (77 kDa, Protein from Homo sapiens)
- Human il-6 in complex with il-6r alpha and detergent-solubilized gp130 (Complex from Homo sapiens)
- Soluble interleukin-6 receptor subunit alpha (38 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Interleukin-6 (20 kDa, Protein from Homo sapiens)