Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7k0i
Q-score: 0.523
Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH
Nat Struct Mol Biol (2021) 28 pp. 240-248 [ Pubmed: 33558761 DOI: doi:10.1038/s41594-020-00551-9 ]
- Serine palmitoyltransferase small subunit a (8 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 1 (52 kDa, Protein from Homo sapiens)
- Human serine palmitoyltransferase complexes (Complex from Homo sapiens)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Serine palmitoyltransferase 2 (60 kDa, Protein from Homo sapiens)
Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa protomer
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7k0j
Q-score: 0.553
Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH
Nat Struct Mol Biol (2021) 28 pp. 240-248 [ Pubmed: 33558761 DOI: doi:10.1038/s41594-020-00551-9 ]
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human serine palmitoyltransferase complexes (Complex from Homo sapiens)
- Serine palmitoyltransferase small subunit a (8 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 1 (52 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 2 (63 kDa, Protein from Homo sapiens)
Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa, 3KS-bound
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7k0k
Q-score: 0.603
Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH
Nat Struct Mol Biol (2021) 28 pp. 240-248 [ Pubmed: 33558761 DOI: doi:10.1038/s41594-020-00551-9 ]
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Human serine palmitoyltransferase complexes (Complex from Homo sapiens)
- 3-dehydrosphinganine (299 Da, Ligand)
- Serine palmitoyltransferase small subunit a (8 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 1 (52 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 2 (63 kDa, Protein from Homo sapiens)
Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7k0m
Q-score: 0.563
Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH
Nat Struct Mol Biol (2021) 28 pp. 240-248 [ Pubmed: 33558761 DOI: doi:10.1038/s41594-020-00551-9 ]
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human serine palmitoyltransferase complexes (Complex from Homo sapiens)
- Serine palmitoyltransferase small subunit a (8 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 1 (52 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 2 (60 kDa, Protein from Homo sapiens)
- Orm1-like protein 3 (17 kDa, Protein from Homo sapiens)
Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7k0n
Q-score: 0.545
Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH
Nat Struct Mol Biol (2021) 28 pp. 240-248 [ Pubmed: 33558761 DOI: doi:10.1038/s41594-020-00551-9 ]
- Serine palmitoyltransferase small subunit a (8 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 1 (52 kDa, Protein from Homo sapiens)
- Human serine palmitoyltransferase complexes (Complex from Homo sapiens)
- Orm1-like protein 3 (17 kDa, Protein from Homo sapiens)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Serine palmitoyltransferase 2 (63 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7k0o
Q-score: 0.537
Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH
Nat Struct Mol Biol (2021) 28 pp. 240-248 [ Pubmed: 33558761 DOI: doi:10.1038/s41594-020-00551-9 ]
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human serine palmitoyltransferase complexes (Complex from Homo sapiens)
- Serine palmitoyltransferase small subunit a (8 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 1 (52 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 2 (60 kDa, Protein from Homo sapiens)
- Orm1-like protein 3 (17 kDa, Protein from Homo sapiens)
Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 4
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7k0p
Q-score: 0.534
Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH
Nat Struct Mol Biol (2021) 28 pp. 240-248 [ Pubmed: 33558761 DOI: doi:10.1038/s41594-020-00551-9 ]
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Human serine palmitoyltransferase complexes (Complex from Homo sapiens)
- Serine palmitoyltransferase small subunit a (8 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 1 (52 kDa, Protein from Homo sapiens)
- Serine palmitoyltransferase 2 (60 kDa, Protein from Homo sapiens)
- Orm1-like protein 3 (17 kDa, Protein from Homo sapiens)