Liu YX, Agard DA, Elnatan D, Sun M, Myasnikov AG
To Be Published
- Trap1 (Protein from Homo sapiens)
- Human trap1 in complex with sdhb in the presence of amp-pnp (162 kDa, Complex from Homo sapiens)
- Sdhb (Protein from Homo sapiens)
Human TRAP1 binding with SdhB folding intermediate state in the presence of AMP-PNP
Liu YX, Agard DA, Elnatan D, Sun M, Myasnikov AG
To Be Published
- Trap1 (Protein from Homo sapiens)
- Human trap1 in complex with sdhb in the presence of amp-pnp (162 kDa, Complex from Homo sapiens)
- Sdhb (Protein from Homo sapiens)
Cryo-EM structure of the yeast chromatin modifying complex SAGA
Sharov G, Voltz K, Durand A, Kolesnikova O, Papai G, Myasnikov AG, Dejaegere A, Shem AB, Schultz P
Nat Commun (2017) 8 pp. 1556-1556 [ DOI: doi:10.1038/s41467-017-01564-7 Pubmed: 29146944 ]
Structure-function insights reveal the human ribosome as a cancer target for antibiotics
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5lks
Q-score: 0.429
Myasnikov AG, Kundhavai Natchiar S, Nebout M, Hazemann I, Imbert V, Khatter H, Peyron JF, Klaholz BP
Nat Commun (2016) 7 pp. 12856-12856 [ DOI: doi:10.1038/ncomms12856 Pubmed: 27665925 ]
- 40s ribosomal protein s29 (6 kDa, Protein from Human)
- 60s ribosomal protein l32 (15 kDa, Protein from Human)
- 60s ribosomal protein l13a (23 kDa, Protein from Human)
- 60s ribosomal protein l36 (12 kDa, Protein from Human)
- 40s ribosomal protein s15 (17 kDa, Protein from Human)
- 60s ribosomal protein l34 (13 kDa, Protein from Human)
- 60s ribosomal protein l36a (12 kDa, Protein from Human)
- 40s ribosomal protein s8 (24 kDa, Protein from Human)
- 5s ribosomal rna (38 kDa, RNA from Human)
- 60s ribosomal protein l6 (32 kDa, Protein from Human)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Human)
- 40s ribosomal protein s24 (15 kDa, Protein from Human)
- 60s ribosomal protein l23a (17 kDa, Protein from Human)
- 60s ribosomal protein l17 (21 kDa, Protein from Human)
- 40s ribosomal protein s12 (14 kDa, Protein from Human)
- 5.8s ribosomal rna (50 kDa, RNA from Human)
- 60s ribosomal protein l37 (11 kDa, Protein from Human)
- 60s ribosomal protein l39 (6 kDa, Protein from Human)
- 40s ribosomal protein s11 (18 kDa, Protein from Human)
- 40s ribosomal protein s16 (16 kDa, Protein from Human)
- 60s ribosomal protein l24 (17 kDa, Protein from Human)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Human)
- 60s ribosomal protein l9 (21 kDa, Protein from Human)
- 60s ribosomal protein l11 (20 kDa, Protein from Human)
- 40s ribosomal protein s3 (26 kDa, Protein from Human)
- 40s ribosomal protein s9 (22 kDa, Protein from Human)
- 40s ribosomal protein s20 (13 kDa, Protein from Human)
- 60s ribosomal protein l18a (20 kDa, Protein from Human)
- 60s ribosomal protein l35a (12 kDa, Protein from Human)
- 40s ribosomal protein s13 (17 kDa, Protein from Human)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l3 (46 kDa, Protein from Human)
- 60s ribosomal protein l23 (14 kDa, Protein from Human)
- Ribosomal protein s30 (14 kDa, Protein from Human)
- 60s ribosomal protein l38 (8 kDa, Protein from Human)
- 60s ribosomal protein l22 (14 kDa, Protein from Human)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Human)
- 60s ribosomal protein l8 (28 kDa, Protein from Human)
- 40s ribosomal protein s19 (16 kDa, Protein from Human)
- 60s ribosomal protein l41 (3 kDa, Protein from Human)
- 60s ribosomal protein l18 (21 kDa, Protein from Human)
- 40s ribosomal protein s6 (28 kDa, Protein from Human)
- 40s ribosomal protein sa (32 kDa, Protein from Human)
- 60s ribosomal protein l30 (12 kDa, Protein from Human)
- 60s ribosomal protein l27a (16 kDa, Protein from Human)
- 4-{(2r)-2-[(1s,3s,5s)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione (281 Da, Ligand)
- 40s ribosomal protein s23 (15 kDa, Protein from Human)
- 60s ribosomal protein l15 (24 kDa, Protein from Human)
- Water (18 Da, Ligand)
- 40s ribosomal protein s17 (15 kDa, Protein from Human)
- 40s ribosomal protein s15a (14 kDa, Protein from Human)
- 40s ribosomal protein s27 (9 kDa, Protein from Human)
- Ribosomal protein l29, isoform cra_a (17 kDa, Protein from Human)
- 60s ribosomal protein l19 (23 kDa, Protein from Human)
- 60s ribosomal protein l14 (23 kDa, Protein from Human)
- 60s ribosomal protein l7 (29 kDa, Protein from Human)
- 60s ribosomal protein l4 (47 kDa, Protein from Human)
- 60s ribosomal protein l35 (14 kDa, Protein from Human)
- 60s ribosomal protein l28 (15 kDa, Protein from Human)
- 60s ribosomal protein l5 (34 kDa, Protein from Human)
- 40s ribosomal protein s2 (31 kDa, Protein from Human)
- 40s ribosomal protein s5 (22 kDa, Protein from Human)
- Ubiquitin-40s ribosomal protein s27a (18 kDa, Protein from Human)
- 60s ribosomal protein l10a (24 kDa, Protein from Human)
- Magnesium ion (24 Da, Ligand)
- 40s ribosomal protein s10 (18 kDa, Protein from Human)
- 60s ribosomal protein l37a (10 kDa, Protein from Human)
- 40s ribosomal protein s25 (13 kDa, Protein from Human)
- 40s ribosomal protein s3a (30 kDa, Protein from Human)
- 40s ribosomal protein s7 (22 kDa, Protein from Human)
- 18s ribosomal rna (602 kDa, RNA from Human)
- 60s ribosomal protein l21 (18 kDa, Protein from Human)
- 60s ribosomal protein l10-like (24 kDa, Protein from Human)
- 60s ribosomal protein l13 (24 kDa, Protein from Human)
- 60s ribosomal protein l31 (14 kDa, Protein from Human)
- 40s ribosomal protein s28 (7 kDa, Protein from Human)
- 60s ribosomal protein l7a (30 kDa, Protein from Human)
- 40s ribosomal protein s14 (16 kDa, Protein from Human)
- Human 80s ribsome (Complex from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Human)
- 60s ribosomal protein l27 (15 kDa, Protein from Human)
- 40s ribosomal protein s21 (9 kDa, Protein from Human)
- 60s ribosomal protein l26 (17 kDa, Protein from Human)
- 28s ribosomal rna (1 MDa, RNA from Human)
- 40s ribosomal protein s26 (13 kDa, Protein from Human)
Resolution: 5.8 Å
EM Method: Single-particle
Fitted PDBs: 5k0y
Q-score: 0.141
Simonetti A, Brito Querido J, Myasnikov AG, Mancera-Martinez E, Renaud A, Kuhn L, Hashem Y
Mol Cell (2016) 63 pp. 206-217 [ Pubmed: 27373335 DOI: doi:10.1016/j.molcel.2016.05.033 ]
- Eukaryotic initiation factor 2 subunit beta (eif2-beta) (2 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es10 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us12 (15 kDa, Protein from Oryctolagus cuniculus)
- 18s ribosomal rna (572 kDa, RNA from Oryctolagus cuniculus)
- Ribosomal protein es1 (24 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us19 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us9 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es31 (8 kDa, Protein from Oryctolagus cuniculus)
- Trna (24 kDa, RNA from Oryctolagus cuniculus)
- Ribosomal protein us3 (25 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us11 (14 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic initiation factor 2 gamma subunit (eif2-gamma) (45 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es25 (8 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us14 (6 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es28 (7 kDa, Protein from Oryctolagus cuniculus)
- Mrna (9 kDa, RNA from Oryctolagus cuniculus)
- 40s ribosomal protein s24 (15 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us17 (18 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us5 (24 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein s9 (predicted) (21 kDa, Protein from Oryctolagus cuniculus)
- M48s late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eif2 ternary complex and eif3 i and g subunits relocated to the intersubunit face (2 MDa, Complex)
- Ribosomal protein us2 (23 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us7 (21 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 2 subunit 1 (30 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s27 (9 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit g (8 kDa, Protein from Homo sapiens)
- Ribosomal protein es7 (21 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s6 (27 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s21 (8 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s4 (29 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us8 (14 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us10 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es26 (11 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es19 (15 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit g (4 kDa, Protein from Homo sapiens)
- Ribosomal protein es17 (14 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us15 (17 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s12 (13 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein us13 (16 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein rack1 (34 kDa, Protein from Oryctolagus cuniculus)
- Eukaryotic translation initiation factor 3 subunit i (37 kDa, Protein from Oryctolagus cuniculus)
- Ribosomal protein es30 (6 kDa, Protein from Oryctolagus cuniculus)
- 40s ribosomal protein s8 (23 kDa, Protein from Oryctolagus cuniculus)
Resolution: 5.8 Å
EM Method: Single-particle
Fitted PDBs: 5k1h
Q-score: -0.011
Simonetti A, Brito Querido J, Myasnikov AG, Mancera-Martinez E, Renaud A, Kuhn L, Hashem Y
Mol Cell (2016) 63 pp. 206-217 [ DOI: doi:10.1016/j.molcel.2016.05.033 Pubmed: 27373335 ]