SARS-CoV-2-Induced Reshaping of Subcellular Morphologies
Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Kohrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y, Bartenschlager R
Cell Host Microbe (2020) 28 pp. 853-866.e5 [ Pubmed: 33245857 DOI: doi:10.1016/j.chom.2020.11.003 ]
Integrative imaging reveals SARS-CoV-2 induced reshaping of subcellular morphology
Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Köhrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y, Bartenschlager R
Cell Host Microbe (2020) [ Pubmed: 33245857 DOI: 10.1016/j.chom.2020.11.003 ]
Image sets:
- Mock cells - Dual axis tilt series
- MOI5-24h-Reconstructed tomograms
- MOI0.5-24h-Reconstructed tomograms
- MOI5-12h-Dual axis tilt series
- MOI5-12h-Reconstructed tomograms
- MOI0.5-24h-Dual axis tilt series
- S5 Mock Cell 1 FIB-SEM Volume 8nm isotropic
- Mock cells-Reconstructed tomograms
- MOI5-6h-Dual axis tilt series
- MOI5-24h-Dual axis tilt series
- S4 Area 3 FIB-SEM Volume 8nm isotropic
- MOI5-6h-Reconstructed tomograms
- S4 Area 2 FIB-SEM Volume 8nm isotropic
- S4 Cell 1 FIB-SEM Volume 5nm isotropic
Tomogram of SARS-CoV-2 infected and cryo-FIB milled VeroE6 cells
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ DOI: doi:10.1038/s41467-020-19619-7 Pubmed: 33208793 ]
Cryo-ET of SARS-CoV-2 infected VeroE6 cells showing budding virions.
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ DOI: doi:10.1038/s41467-020-19619-7 Pubmed: 33208793 ]
SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ DOI: doi:10.1038/s41467-020-19619-7 Pubmed: 33208793 ]
Cryo-ET of SARS-CoV-2 virions released from VerE6 cells
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ DOI: doi:10.1038/s41467-020-19619-7 Pubmed: 33208793 ]
Subtomogram average of SARS-CoV-2 vRNP
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ DOI: doi:10.1038/s41467-020-19619-7 Pubmed: 33208793 ]
Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions
Ke Z, Oton J, Qu K, Cortese M, Zila V, McKeane L, Nakane T, Zivanov J, Neufeldt CJ, Cerikan B, Lu JM, Peukes J, Xiong X, Kräusslich HG, Scheres SHW, Bartenschlager R, Briggs JAG
Nature (2020) [ Pubmed: 32805734 DOI: 10.1038/s41586-020-2665-2 ]
Image sets:
Subtomogram averaging and classification of SARS-CoV-2 Spike Proteins on intact virions
Ke Z, Oton J, Qu K, Cortese M, Zila V, McKeane L, Nakane T, Zivanov J, Neufeldt CJ, Cerikan B, Lu JM, Peukes J, Xiong X, Kräusslich HG, Scheres SHW, Bartenschlager R, Briggs JAG
Nature (2020) [ Pubmed: 32805734 DOI: 10.1038/s41586-020-2665-2 ]
Image sets:
Ke Z, Oton J, Qu K, Cortese M, Zila V, McKeane L, Nakane T, Zivanov J, Neufeldt CJ, Cerikan B, Lu JM, Peukes J, Xiong X, Krausslich HG, Scheres SHW, Bartenschlager R, Briggs JAG
Nature (2020) 588 pp. 498-502 [ Pubmed: 32805734 DOI: doi:10.1038/s41586-020-2665-2 ]