SARS-CoV-2-Induced Reshaping of Subcellular Morphologies
Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Kohrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y, Bartenschlager R
Cell Host Microbe (2020) 28 pp. 853-866.e5 [ DOI: doi:10.1016/j.chom.2020.11.003 Pubmed: 33245857 ]
Integrative imaging reveals SARS-CoV-2 induced reshaping of subcellular morphology
Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, Köhrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y, Bartenschlager R
Cell Host Microbe (2020) [ Pubmed: 33245857 DOI: 10.1016/j.chom.2020.11.003 ]
Image sets:
- MOI5-12h-Dual axis tilt series
- S4 Cell 1 FIB-SEM Volume 5nm isotropic
- MOI0.5-24h-Dual axis tilt series
- MOI0.5-24h-Reconstructed tomograms
- S4 Area 3 FIB-SEM Volume 8nm isotropic
- S4 Area 2 FIB-SEM Volume 8nm isotropic
- MOI5-12h-Reconstructed tomograms
- MOI5-6h-Reconstructed tomograms
- S5 Mock Cell 1 FIB-SEM Volume 8nm isotropic
- Mock cells - Dual axis tilt series
- Mock cells-Reconstructed tomograms
- MOI5-24h-Dual axis tilt series
- MOI5-24h-Reconstructed tomograms
- MOI5-6h-Dual axis tilt series
Tomogram of SARS-CoV-2 infected and cryo-FIB milled VeroE6 cells
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ Pubmed: 33208793 DOI: doi:10.1038/s41467-020-19619-7 ]
Cryo-ET of SARS-CoV-2 infected VeroE6 cells showing budding virions.
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ Pubmed: 33208793 DOI: doi:10.1038/s41467-020-19619-7 ]
SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ Pubmed: 33208793 DOI: doi:10.1038/s41467-020-19619-7 ]
Cryo-ET of SARS-CoV-2 virions released from VerE6 cells
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ Pubmed: 33208793 DOI: doi:10.1038/s41467-020-19619-7 ]
Subtomogram average of SARS-CoV-2 vRNP
Klein S, Cortese M, Winter SL, Wachsmuth-Melm M, Neufeldt CJ, Cerikan B, Stanifer ML, Boulant S, Bartenschlager R, Chlanda P
Nat Commun (2020) 11 pp. 5885-5885 [ Pubmed: 33208793 DOI: doi:10.1038/s41467-020-19619-7 ]
Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions
Ke Z, Oton J, Qu K, Cortese M, Zila V, McKeane L, Nakane T, Zivanov J, Neufeldt CJ, Cerikan B, Lu JM, Peukes J, Xiong X, Kräusslich HG, Scheres SHW, Bartenschlager R, Briggs JAG
Nature (2020) [ DOI: 10.1038/s41586-020-2665-2 Pubmed: 32805734 ]
Image sets:
Subtomogram averaging and classification of SARS-CoV-2 Spike Proteins on intact virions
Ke Z, Oton J, Qu K, Cortese M, Zila V, McKeane L, Nakane T, Zivanov J, Neufeldt CJ, Cerikan B, Lu JM, Peukes J, Xiong X, Kräusslich HG, Scheres SHW, Bartenschlager R, Briggs JAG
Nature (2020) [ DOI: 10.1038/s41586-020-2665-2 Pubmed: 32805734 ]
Image sets:
Ke Z, Oton J, Qu K, Cortese M, Zila V, McKeane L, Nakane T, Zivanov J, Neufeldt CJ, Cerikan B, Lu JM, Peukes J, Xiong X, Krausslich HG, Scheres SHW, Bartenschlager R, Briggs JAG
Nature (2020) 588 pp. 498-502 [ Pubmed: 32805734 DOI: doi:10.1038/s41586-020-2665-2 ]