Cryo-EM structure of the RAF1-HSP90-CDC37 complex in the closed state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8u1l
Q-score: 0.282
Finci LI, Chakrabarti M, Gulten G, Finney J, Grose C, Fox T, Yang R, Nissley DV, McCormick F, Esposito D, Balius TE, Simanshu DK
Commun Biol (2024) 7 pp. 260-260 [ Pubmed: 38431713 DOI: doi:10.1038/s42003-024-05959-3 ]
- Raf1 & hsp90 co-chaperone cdc37 (Complex from Homo sapiens)
- Heat shock protein 83 (83 kDa, Protein from Trichoplusia ni)
- Hsp90 co-chaperone cdc37, n-terminally processed (44 kDa, Protein from Homo sapiens)
- Raf proto-oncogene serine/threonine-protein kinase (74 kDa, Protein from Homo sapiens)
- Heat shock protein 90 (Complex from Trichoplusia ni)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Complex of raf1-hsp90-cdc37 (Complex)
Cryo-EM structure of the HSP90 dimer (NTD-MD) in the semi-open state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8u1m
Q-score: 0.261
Finci LI, Chakrabarti M, Gulten G, Finney J, Grose C, Fox T, Yang R, Nissley DV, McCormick F, Esposito D, Balius TE, Simanshu DK
Commun Biol (2024) 7 pp. 260-260 [ Pubmed: 38431713 DOI: doi:10.1038/s42003-024-05959-3 ]
- Heat shock protein 83 (83 kDa, Protein from Trichoplusia ni)
- Heat shock protein 90 (166 kDa, Complex from Trichoplusia ni)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of the cross-linked HSP90 dimer (NTD-MD) in the semi-open state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8u1n
Q-score: 0.333
Finci LI, Chakrabarti M, Gulten G, Finney J, Grose C, Fox T, Yang R, Nissley DV, McCormick F, Esposito D, Balius TE, Simanshu DK
Commun Biol (2024) 7 pp. 260-260 [ Pubmed: 38431713 DOI: doi:10.1038/s42003-024-05959-3 ]
- Heat shock protein 83 (83 kDa, Protein from Trichoplusia ni)
- Heat shock protein 90 (166 kDa, Complex from Trichoplusia ni)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of the full-length human NF1 dimer
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8edm
Q-score: 0.349
Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F
PNAS (2023) 120 pp. e2208960120-e2208960120 [ DOI: doi:10.1073/pnas.2208960120 Pubmed: 36689660 ]
- Isoform i of neurofibromin (317 kDa, Protein from Homo sapiens)
- Full-length human nf1 (320 kDa, Complex from Homo sapiens)
Cryo-EM structure of the full-length human NF1 dimer
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8e20
Q-score: 0.323
Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F
PNAS (2023) 120 pp. e2208960120-e2208960120 [ DOI: doi:10.1073/pnas.2208960120 Pubmed: 36689660 ]
- Isoform i of neurofibromin (317 kDa, Protein from Homo sapiens)
- Full-length human nf1 (320 MDa, Complex from Homo sapiens)
Sherekar M, Han SW, Ghirlando R, Messing S, Drew M, Rabara D, Waybright T, Juneja P, O'Neill H, Stanley CB, Bhowmik D, Ramanathan A, Subramaniam S, Nissley DV, Gillette W, McCormick F, Esposito D
J Biol Chem (2020) 295 pp. 1105-1119 [ DOI: doi:10.1074/jbc.RA119.010934 Pubmed: 31836666 ]