Inactive Mu-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound #33
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 9mqh
Q-score: 0.431
Vigneron SF, Ohno S, Braz J, Kim JY, Kweon OS, Webb C, Billesbolle C, Bhardwaj K, Irwin J, Manglik A, Basbaum AI, Ellman JA, Shoichet BK
bioRxiv (2025) [ DOI: doi:10.1101/2025.01.09.632033 Pubmed: 39868130 ]
- Mu-type opioid receptor (46 kDa, Protein from Homo sapiens)
- Human mu-opioid receptor (46 MDa, Complex from Homo sapiens)
Inactive Mu-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound#020_E1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9mqi
Q-score: 0.352
Vigneron SF, Ohno S, Braz J, Kim JY, Kweon OS, Webb C, Billesbolle C, Bhardwaj K, Irwin J, Manglik A, Basbaum AI, Ellman JA, Shoichet BK
bioRxiv (2025) [ DOI: doi:10.1101/2025.01.09.632033 Pubmed: 39868130 ]
- Nanobody 6m (14 kDa, Protein from synthetic construct)
- Mu-type opioid receptor (46 kDa, Protein from Homo sapiens)
- Nabfab light chain (23 kDa, Protein from synthetic construct)
- Nabfab heavy chain (25 kDa, Protein from synthetic construct)
- Methyl (1s,3r,4s,6s,8m)-2-[(1-ethyl-1h-pyrazol-4-yl)methyl]-8-(3-hydroxyphenyl)-3,4-dimethyl-2-azabicyclo[2.2.2]oct-7-ene-6-carboxylate (395 Da, Ligand)
- Human mu-opioid receptor (46 MDa, Complex from Homo sapiens)
Locally-refined Inactive Mu-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound #020_E1
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 9mqj
Q-score: 0.402
Vigneron SF, Ohno S, Braz J, Kim JY, Kweon OS, Webb C, Billesbolle C, Bhardwaj K, Irwin J, Manglik A, Basbaum AI, Ellman JA, Shoichet BK
bioRxiv (2025) [ DOI: doi:10.1101/2025.01.09.632033 Pubmed: 39868130 ]
Inactive Kappa-Opioid Receptor with Nb6M, NabFab, and isoquinuclidine compound #020_E1
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 9mqk
Q-score: 0.466
Vigneron SF, Ohno S, Braz J, Kim JY, Kweon OS, Webb C, Billesbolle C, Bhardwaj K, Irwin J, Manglik A, Basbaum AI, Ellman JA, Shoichet BK
bioRxiv (2025) [ DOI: doi:10.1101/2025.01.09.632033 Pubmed: 39868130 ]
- Nanobody 6m (14 kDa, Protein from synthetic construct)
- Nabfab light chain (23 kDa, Protein from synthetic construct)
- Nabfab heavy chain (25 kDa, Protein from synthetic construct)
- Methyl (1s,3r,4s,6s,8m)-2-[(1-ethyl-1h-pyrazol-4-yl)methyl]-8-(3-hydroxyphenyl)-3,4-dimethyl-2-azabicyclo[2.2.2]oct-7-ene-6-carboxylate (395 Da, Ligand)
- Human kappa-opioid receptor (46 MDa, Complex from Homo sapiens)
- Kappa-opioid receptor (43 kDa, Protein from Homo sapiens)
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 9mql
Q-score: 0.559
Vigneron SF, Ohno S, Braz J, Kim JY, Kweon OS, Webb C, Billesbolle C, Bhardwaj K, Irwin J, Manglik A, Basbaum AI, Ellman JA, Shoichet BK
bioRxiv (2025) [ DOI: doi:10.1101/2025.01.09.632033 Pubmed: 39868130 ]
Melero R, Uchiyama A, Castano R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O
Structure (2014) 22 pp. 1105-1119 [ Pubmed: 25002321 DOI: doi:10.1016/j.str.2014.05.015 ]
- Serine/threonine-protein kinase smg1 (410 kDa, Protein from Homo sapiens)
- Smg1 kinase (410 kDa, Sample)
Structure of SMG1C complex, comprising SMG1 kinase, SMG8 and SMG9
Melero R, Uchiyama A, Castano R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O
Structure (2014) 22 pp. 1105-1119 [ Pubmed: 25002321 DOI: doi:10.1016/j.str.2014.05.015 ]
- Smg1c complex, comprising smg1 kinase, smg8 and smg9 (580 kDa, Sample)
- Smg9 (60 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase smg1 (410 kDa, Protein from Homo sapiens)
- Smg8 (109 kDa, Protein from Homo sapiens)
Structure of SMG1C-UPF1 complex, comprising SMG1 kinase, SMG8, SMG9 and UPF1
Melero R, Uchiyama A, Castano R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O
Structure (2014) 22 pp. 1105-1119 [ Pubmed: 25002321 DOI: doi:10.1016/j.str.2014.05.015 ]
- Smg8 (109 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase smg1 (410 kDa, Protein from Homo sapiens)
- Smg9 (60 kDa, Protein from Homo sapiens)
- Smg1c-upf1 complex, comprising smg1 kinase, smg8, smg9 and upf1 (700 kDa, Sample)
- Upf1 (120 kDa, Protein from Homo sapiens)
Structure of SMG1C-UPF2 complex, comprising SMG1 kinase, SMG8, SMG9 and UPF2
Melero R, Uchiyama A, Castano R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O
Structure (2014) 22 pp. 1105-1119 [ Pubmed: 25002321 DOI: doi:10.1016/j.str.2014.05.015 ]
- Smg8 (109 kDa, Protein from Homo sapiens)
- Upf2 (148 kDa, Protein from Homo sapiens)
- Smg1c-upf2 complex, comprising smg1 kinase, smg8, smg9 and upf2 (730 kDa, Sample)
- Serine/threonine-protein kinase smg1 (410 kDa, Protein from Homo sapiens)
- Smg9 (60 kDa, Protein from Homo sapiens)
Structure of SMG1C-UPF1-UPF2 complex, comprising SMG1 kinase, SMG8, SMG9, UPF1 and UPF2
Melero R, Uchiyama A, Castano R, Kataoka N, Kurosawa H, Ohno S, Yamashita A, Llorca O
Structure (2014) 22 pp. 1105-1119 [ Pubmed: 25002321 DOI: doi:10.1016/j.str.2014.05.015 ]
- Smg8 (109 kDa, Protein from Homo sapiens)
- Upf2 (148 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase smg1 (410 kDa, Protein from Homo sapiens)
- Smg1c-upf1-upf2 complex, comprising smg1 kinase, smg8, smg9, upf1 and upf2 (850 kDa, Sample)
- Smg9 (60 kDa, Protein from Homo sapiens)
- Upf1 (120 kDa, Protein from Homo sapiens)