SARS-CoV-2 M protein dimer (short form) in complex with Fab-B and CIM-834
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9exa
Q-score: 0.503
Laporte M, Jochmans D, Bardiot D, Desmarets L, Debski-Antoniak OJ, Mizzon G, Abdelnabi R, Leyssen P, Chiu W, Zhang Z, Nomura N, Bolland S, Ohto U, Stahl Y, Wuyts J, De Jonghe S, Dubuisson J, Bosch BJ, van Kuppeveld JM, Eydoux C, Decroly E, Canard B, Naesens L, Snijder E, Belouzard S, Shimizu T, Bartenschlager R, Hurdiss DL, Marchand A, Chaltin P, Neyts J
To Be Published
- 6-[[1-[4,6-dimethyl-5-(2-methylpropyl)pyrimidin-2-yl]piperidin-4-yl]-methyl-amino]-n-(2-pyrrolidin-1-ylethyl)pyridazine-4-carboxamide (494 Da, Ligand)
- Sars-cov-2 m protein dimer (short form) in complex with fab-b and cim-834 (154 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab-b light chain (23 kDa, Protein from Mus musculus)
- Fab-b heavy chain (22 kDa, Protein from Mus musculus)
- Membrane protein (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Human Fc epsilon RI in complex with hIgE Fc (TMD disordered)
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 8k7r
Q-score: 0.452
Zhang Z, Yui M, Ohto U, Shimizu T
Sci Signal (2024) 17 pp. eadn1303-eadn1303 [ DOI: doi:10.1126/scisignal.adn1303 Pubmed: 39656861 ]
- High affinity immunoglobulin epsilon receptor subunit alpha (32 kDa, Protein from Homo sapiens)
- Ige fc (39 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human fc epsilon ri in complex with hige fc (Complex from Homo sapiens)
Human Fc epsilon RI in complex with mIgE Fc (TMD disordered)
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8k7s
Q-score: 0.358
Zhang Z, Yui M, Ohto U, Shimizu T
Sci Signal (2024) 17 pp. eadn1303-eadn1303 [ DOI: doi:10.1126/scisignal.adn1303 Pubmed: 39656861 ]
- Fcer1a (32 kDa, Protein from Homo sapiens)
- Ige fc (40 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human fc epsilon ri in complex with mige fc (Complex from Homo sapiens)
Cryo-EM structure of mouse SLC15A3 (outward-facing open)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8wx1
Q-score: 0.384
Zhang Z, Kasai S, Sakaniwa K, Fujimura A, Ohto U, Shimizu T
To Be Published
- Mouse slc15a3 (Complex)
- Mouse slc15a3 (Complex from Mus musculus)
- Solute carrier family 15 member 3 (64 kDa, Protein from Mus musculus)
Mouse Fc epsilon RI in complex with mIgE Fc
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8k7t
Q-score: 0.37
Zhang Z, Yui M, Ohto U, Shimizu T
Sci Signal (2024) 17 pp. eadn1303-eadn1303 [ DOI: doi:10.1126/scisignal.adn1303 Pubmed: 39656861 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mouse fc epsilon ri in complex with mige fc (Complex from Mus musculus)
- High affinity immunoglobulin epsilon receptor subunit alpha (31 kDa, Protein from Mus musculus)
- High affinity immunoglobulin epsilon receptor subunit gamma (11 kDa, Protein from Mus musculus)
- Ige fc (40 kDa, Protein from Mus musculus)
- High affinity immunoglobulin epsilon receptor subunit beta (27 kDa, Protein from Mus musculus)
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 8yrj
Q-score: 0.271
Zhang Z, Yui M, Ohto U, Shimizu T
Sci Signal (2024) 17 pp. eadn1303-eadn1303 [ DOI: doi:10.1126/scisignal.adn1303 Pubmed: 39656861 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- High affinity immunoglobulin epsilon receptor subunit gamma (11 kDa, Protein from Mus musculus)
- High affinity immunoglobulin epsilon receptor subunit alpha (31 kDa, Protein from Mus musculus)
- Mouse fc epsilon ri (Complex from Mus musculus)
- High affinity immunoglobulin epsilon receptor subunit beta (27 kDa, Protein from Mus musculus)
Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8wx4
Q-score: 0.514
Zhang Z, Kasai S, Sakaniwa K, Fujimura A, Ohto U, Shimizu T
To Be Published
- Leucine (131 Da, Ligand)
- Lysine (147 Da, Ligand)
- Solute carrier family 15 member 4 (64 kDa, Protein from Homo sapiens)
- Human slc15a4 with kl (Complex from Homo sapiens)
Cryo-EM structure of human SLC15A4 in complex with TASL (inward-facing open)
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8wx5
Q-score: 0.36
Zhang Z, Kasai S, Sakaniwa K, Fujimura A, Ohto U, Shimizu T
To Be Published
- Human slc15a4 and tasl complex (Complex from Homo sapiens)
- Tasl (tasl-slc15a4 fusion protein) (1 kDa, Protein from Homo sapiens)
- Solute carrier family 15 member 4 (64 kDa, Protein from Homo sapiens)
Cryo-EM structure of human SLC15A3 (dimer)
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 8wx2
Q-score: 0.324
Zhang Z, Kasai S, Sakaniwa K, Fujimura A, Ohto U, Shimizu T
To Be Published
- Solute carrier family 15 member 3 (67 kDa, Protein from Homo sapiens)
- Human slc15a3 (Complex from Homo sapiens)