Cryo-EM structure of human SLC15A4 in complex with Lys-Leu (outward-facing open)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8wx4
Q-score: 0.514
Zhang Z, Kasai S, Sakaniwa K, Fujimura A, Ohto U, Shimizu T
To Be Published
- Leucine (131 Da, Ligand)
- Lysine (147 Da, Ligand)
- Solute carrier family 15 member 4 (64 kDa, Protein from Homo sapiens)
- Human slc15a4 with kl (Complex from Homo sapiens)
Cryo-EM structure of human SLC15A4 in complex with TASL (inward-facing open)
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8wx5
Q-score: 0.36
Zhang Z, Kasai S, Sakaniwa K, Fujimura A, Ohto U, Shimizu T
To Be Published
- Human slc15a4 and tasl complex (Complex from Homo sapiens)
- Tasl (tasl-slc15a4 fusion protein) (1 kDa, Protein from Homo sapiens)
- Solute carrier family 15 member 4 (64 kDa, Protein from Homo sapiens)
Cryo-EM structure of human SLC15A4 (outward-facing open)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8wx3
Q-score: 0.573
Zhang Z, Kasai S, Sakaniwa K, Fujimura A, Ohto U, Shimizu T
To Be Published
- Human slc15a4 (Complex from Homo sapiens)
- Solute carrier family 15 member 4 (64 kDa, Protein from Homo sapiens)
Cryo-EM structure of human NTCP complexed with YN69202Fab
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 7vad
Q-score: 0.399
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Fab (Complex)
- Complex of ntcp and fab (Complex from Homo sapiens)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
- Ntcp: (Complex from Mus musculus)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7vag
Q-score: 0.401
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Ntcp (Complex from Mus musculus)
- Complex of ntcp and fab in the presence of myristoylated pres1 peptide (Complex from Homo sapiens)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
- Fab (Complex)
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
Cryo-EM structure of human NTCP (wild-type) complexed with YN69202Fab
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7wsi
Q-score: 0.434
Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U
Nature (2022) 606 pp. 1021-1026 [ DOI: doi:10.1038/s41586-022-04845-4 Pubmed: 35580629 ]
- Fab light chain from antibody igg clone number yn69202 (24 kDa, Protein from Mus musculus)
- Fab heavy chain from antibody igg clone number yn69202 (26 kDa, Protein from Mus musculus)
- Fab (Complex)
- Complex of ntcp and fab (Complex from Homo sapiens)
- Ntcp (Complex from Homo sapiens)
- Sodium/bile acid cotransporter (38 kDa, Protein from Homo sapiens)