Structure of Apo CXCR4/Gi complex
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8u4n
Q-score: 0.56
Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
Nat Struct Mol Biol (2025) 32 pp. 315-325 [ DOI: doi:10.1038/s41594-024-01397-1 Pubmed: 39313635 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Apo cxcr4/gi complex (Complex from Homo sapiens)
CryoEM structure of PN45545 TCR-CD3 in complex with HLA-A2 MAGEA4 (230-239)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8es8
Q-score: 0.537
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- Melanoma-associated antigen 4 (1 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Pn45545 tcr alpha chain (30 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45545 tcr beta chain (35 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Pn45545 tcr-cd3 complex bound to hla-a2 magea4 (230-239) with anti-beta-2-microglobulin fab (Complex from Homo sapiens)
Cryo-EM structure of human CNTFR alpha in complex with the Fab fragments of two antibodies
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8d7e
Q-score: 0.517
Zhou Y, Stevis PE, Cao J, Saotome K, Wu J, Glatman Zaretsky A, Haxhinasto S, Yancopoulos GD, Murphy AJ, Sleeman MW, Olson WC, Franklin MC
Sci Adv (2023) 9 pp. eade4395-eade4395 [ DOI: doi:10.1126/sciadv.ade4395 Pubmed: 36930708 ]
- Ciliary neurotrophic factor receptor subunit alpha (39 kDa, Protein from Homo sapiens)
- H4h25311p2 antibody fab fragment heavy chain (23 kDa, Protein from Homo sapiens)
- Regn8938 antibody fab fragment heavy chain (23 kDa, Protein from Homo sapiens)
- Human cntfr alpha in complex with the fab fragments of two antibodies (Complex from Homo sapiens)
- Regn8938 antibody fab fragment light chain (23 kDa, Protein from Homo sapiens)
- H4h25311p2 antibody fab fragment light chain (23 kDa, Protein from Homo sapiens)