Cryo-EM structure of the E396A mutant of human TRPM4 in complex with calcium at 37 degrees Celsius
Cryo-EM structure of the human TRPM4 in complex with calcium at 37 degrees Celsius
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium 37 degrees Celsius
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9b8y
Q-score: 0.458
Hu J, Park SJ, Walter T, Orozco IJ, O'Dea G, Ye X, Du J, Lu W
Nature (2024) 630 pp. 509-515 [ Pubmed: 38750366 DOI: doi:10.1038/s41586-024-07436-7 ]
- Decavanadate (957 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (134 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Cryo-em structure of the human trpm4 channel in complex with calcium and decavanadate at 37 degrees celsius (Complex from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9b8z
Q-score: 0.451
Hu J, Park SJ, Walter T, Orozco IJ, O'Dea G, Ye X, Du J, Lu W
Nature (2024) 630 pp. 509-515 [ Pubmed: 38750366 DOI: doi:10.1038/s41586-024-07436-7 ]
- Decavanadate (957 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (134 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Human trpm4 channel subunit in complex with calcium and decavanadate at 37 degrees celsius (Complex from Homo sapiens)
Cryo-EM structure of the human TRPM4 channel in complex with calcium and ATP at 37 degrees Celsius
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9b90
Q-score: 0.411
Hu J, Park SJ, Walter T, Orozco IJ, O'Dea G, Ye X, Du J, Lu W
Nature (2024) 630 pp. 509-515 [ Pubmed: 38750366 DOI: doi:10.1038/s41586-024-07436-7 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 4 (134 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human trpm4 channel in complex with calcium and atp at 37 degrees celsius (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9b91
Q-score: 0.425
Hu J, Park SJ, Walter T, Orozco IJ, O'Dea G, Ye X, Du J, Lu W
Nature (2024) 630 pp. 509-515 [ Pubmed: 38750366 DOI: doi:10.1038/s41586-024-07436-7 ]
- Transient receptor potential cation channel subfamily m member 4 (134 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Cryo-em structure of the human trpm4 channel subunit in complex with calcium and atp at 37 degrees celsius (Complex from Homo sapiens)
Cryo-EM structure of the human TRPM4 in complex with calcium at 18 degrees Celsius
Cryo-EM structure of the human TRPM4 channel in the presence of EDTA at 37 degrees Celsius
Cryo-EM structure of zebrafish TRPM5 in the presence of 1 mM EDTA
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7mbp
Q-score: 0.534
Ruan Z, Haley E, Orozco IJ, Sabat M, Myers R, Roth R, Du J, Lu W
Nat Struct Mol Biol (2021) 28 pp. 604-613 [ Pubmed: 34168372 DOI: doi:10.1038/s41594-021-00607-4 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2r)-2-(hydroxymethyl)-4-{[(25r)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-o-alpha-d-glucopyranosyl-beta-d-glucopyranoside (841 Da, Ligand)
- Trpm5 channel (Complex from Danio rerio)
- (25r)-14beta,17beta-spirost-5-en-3beta-ol (414 Da, Ligand)
- Transient receptor potential melastatin 5 (132 kDa, Protein from Danio rerio)