Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7lmy
Q-score: 0.512
Pan M, Yu Y, Ai H, Zheng Q, Xie Y, Liu L, Zhao M
Nat Struct Mol Biol (2021) 28 pp. 614-625 [ DOI: doi:10.1038/s41594-021-00617-2 Pubmed: 34262183 ]
- Magnesium ion (24 Da, Ligand)
- Human p97 in complex with nms-873 in the presence of atp, npl4/ufd1, and k48-linked ub6 (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine (520 Da, Ligand)
Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 2)
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7ln0
Q-score: 0.413
Pan M, Yu Y, Ai H, Zheng Q, Xie Y, Liu L, Zhao M
Nat Struct Mol Biol (2021) 28 pp. 614-625 [ DOI: doi:10.1038/s41594-021-00617-2 Pubmed: 34262183 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Human p97 in complex with npl4/ufd1 and k48-linked ub6 in the presence of atp (Complex from Homo sapiens)
- Hexa-ubiquitin (783 Da, Protein from Homo sapiens)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
Human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1 and plyubiquitinated Ub-Eos
Map of human p97 in complex with ATPgammaS and Npl4/Ufd1 (masked around p97 and C6 averaged)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7jy5
Q-score: 0.48
Pan M, Zheng Q, Yu Y, Ai H, Xie Y, Zeng X, Wang C, Liu L, Zhao M
Nat Commun (2021) 12 pp. 121-121 [ DOI: doi:10.1038/s41467-020-20359-x Pubmed: 33402676 ]
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Human p97 in complex with atpgammas and npl4/ufd1 (Complex from Homo sapiens)
Human Teneurin-2 and human Latrophilin-3 binary complex
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 6vhh
Q-score: 0.502
Li J, Xie Y, Cornelius S, Jiang X, Sando R, Kordon SP, Pan M, Leon K, Sudhof TC, Zhao M, Arac D
Nat Commun (2020) 11 pp. 2140-2140 [ Pubmed: 32358586 DOI: doi:10.1038/s41467-020-16029-7 ]
- Adhesion g protein-coupled receptor l3 (95 kDa, Protein from Homo sapiens)
- Teneurin-2 (216 kDa, Protein from Homo sapiens)
- Binary complex of human teneurin-2 with human latrophilin-3 extracellular domain (314 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)