Cryo-EM structure of human S1P transporter SPNS2 bound with S1P
Cryo-EM structure of human S1P transporter SPNS2 bound with an inhibitor 16d
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8jhr
Q-score: 0.46
Pang B, Yu L, Li T, Jiao H, Wu X, Wang J, He R, Zhang Y, Wang J, Hu H, Dai W, Chen L, Ren R
Cell Res (2024) 34 pp. 173-176 [ Pubmed: 38123824 DOI: doi:10.1038/s41422-023-00908-x ]
- Sphingosine-1-phosphate transporter spns2 (60 kDa, Protein from Homo sapiens)
- Wild type spns2 (Complex from Homo sapiens)
- 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine (343 Da, Ligand)
CXCR3-DNGi complex activated by CXCL11
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8hnk
Q-score: 0.532
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ Pubmed: 38177682 DOI: doi:10.1038/s41594-023-01175-5 ]
- C-x-c motif chemokine 11 (11 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Single-chain variable fragment scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- Cxcr3-cxcl11-dngi-scfv16 (Complex from Homo sapiens)
CXCR3-DNGi complex activated by PS372424
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8hnl
Q-score: 0.548
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ DOI: doi:10.1038/s41594-023-01175-5 Pubmed: 38177682 ]
- Single-chain variable fragment scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (3s)-n-[(2s)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1h-isoquinoline-3-carboxamide (588 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Cxcr3-ps372424-dngi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
CXCR3-DNGi complex activated by VUF11222
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8hnm
Q-score: 0.546
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ DOI: doi:10.1038/s41594-023-01175-5 Pubmed: 38177682 ]
- Single-chain variable fragment scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- [4-(2-bromophenyl)phenyl]methyl-[[(1r,5s)-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl]-dimethyl-azanium (425 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cxcr3-vuf11222-dngi-scfv16 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
Structure of CXCR3 complexed with antagonist SCH546738
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8hnn
Q-score: 0.434
Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H
Nat Struct Mol Biol (2024) 31 pp. 610-620 [ Pubmed: 38177682 DOI: doi:10.1038/s41594-023-01175-5 ]
- Cholesterol (386 Da, Ligand)
- 3-azanyl-6-chloranyl-5-[(3s)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide (492 Da, Ligand)
- Nb6 (18 kDa, Protein from Lama glama)
- Cxcr3-kor-sch546738-nb6 (Complex from Homo sapiens)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,kappa-type opioid receptor (56 kDa, Protein from Homo sapiens)
Structure of CXCR3 complexed with antagonist AMG487
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k2w
Q-score: 0.501
Jiao H, Pang B, Chiang YC, Chen Q, Pan Q, Ren R, Hu H
Cell Discov (2023) 9 pp. 119-119 [ Pubmed: 38012179 DOI: doi:10.1038/s41421-023-00617-0 ]
- Cxcr3-kor-amg487-nb6 (Complex from Homo sapiens)
- [1-myristoyl-glycerol-3-yl]phosphonylcholine (468 Da, Ligand)
- N-[(1r)-1-[3-(4-ethoxyphenyl)-4-oxidanylidene-pyrido[2,3-d]pyrimidin-2-yl]ethyl]-n-(pyridin-3-ylmethyl)-2-[4-(trifluoromethyloxy)phenyl]ethanamide (603 Da, Ligand)
- Nb6 (18 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,kappa-type opioid receptor (56 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
CXCR3-DNGi complex activated by CXCL10
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8k2x
Q-score: 0.516
Jiao H, Pang B, Chiang YC, Chen Q, Pan Q, Ren R, Hu H
Cell Discov (2023) 9 pp. 119-119 [ Pubmed: 38012179 DOI: doi:10.1038/s41421-023-00617-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Single-chain variable fragment scfv16 (27 kDa, Protein from Oplophorus gracilirostris)
- Cxcr3-cxcl10-dngi-scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 3,oplophorus-luciferin 2-monooxygenase catalytic subunit (72 kDa, Protein from Oplophorus gracilirostris)
- C-x-c motif chemokine 10 (10 kDa, Protein from Homo sapiens)
Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hj5
Q-score: 0.534
Gan B, Yu L, Yang H, Jiao H, Pang B, Chen Y, Wang C, Lv R, Hu H, Cao Z, Ren R
PLoS Biol (2023) 21 pp. e3001975-e3001975 [ Pubmed: 37347749 DOI: doi:10.1371/journal.pbio.3001975 ]
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x1,lgbit (71 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- N-{2-[(1-aminoisoquinolin-6-yl)oxy]-4-methylphenyl}-2-methoxybenzene-1-sulfonamide (435 Da, Ligand)
- Gq coupled mrgprx1 bound with compound 16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Vicugna pacos)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)