Pre-fusion Measles virus fusion protein complexed with Fab 77
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8ut2
Q-score: 0.583
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ Pubmed: 38935733 DOI: doi:10.1126/science.adm8693 ]
- Mab 77 light chain (25 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
- Antibody 77 fab heavy chain, antibody 77 fab light chain (Complex from Mus musculus)
- Fusion glycoprotein f0 (44 kDa, Protein from Measles morbillivirus)
- Mab 77 heavy chain (52 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles morbillivirus)
- Structure of measles fusion glycoprotein in complex with fab 77 (Complex)
- Measles virus fusion glycoprotein (Complex from Measles morbillivirus)
Structure of the Measles virus Fusion protein in the post-fusion conformation
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8utf
Q-score: 0.572
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ Pubmed: 38935733 DOI: doi:10.1126/science.adm8693 ]
- Fusion glycoprotein f0 (44 kDa, Protein from Measles virus strain Ichinose-B95a)
- Water (18 Da, Ligand)
- Structure of the measles virus fusion protein in the post-fusion conformation (Complex from Measles virus strain Ichinose-B95a)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles virus strain Ichinose-B95a)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the Measles virus Fusion protein in the pre-fusion conformation
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 8uup
Q-score: 0.637
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ Pubmed: 38935733 DOI: doi:10.1126/science.adm8693 ]
- Fusion glycoprotein f0 (44 kDa, Protein from Measles virus strain Ichinose-B95a)
- Water (18 Da, Ligand)
- Structure of the measles virus fusion protein in the pre-fusion conformation (Complex from Measles virus strain Ichinose-B95a)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles virus strain Ichinose-B95a)
Resolution: 2.34 Å
EM Method: Single-particle
Fitted PDBs: 8uuq
Q-score: 0.663
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ Pubmed: 38935733 DOI: doi:10.1126/science.adm8693 ]
- Fusion glycoprotein f0 (44 kDa, Protein from Measles virus strain Ichinose-B95a)
- Water (18 Da, Ligand)
- Structure of the measles virus fusion protein in the pre-fusion conformation with bound [fip-hrc]2-peg11 (Complex from Measles virus strain Ichinose-B95a)
- Fusion glycoprotein f0 (12 kDa, Protein from Measles virus strain Ichinose-B95a)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [fip-hrc]2-peg11 (503 Da, Protein from synthetic construct)
Fab 77-stabilized MeV F ectodomain fragment
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9at8
Q-score: 0.444
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science (2024) 384 pp. eadm8693-eadm8693 [ Pubmed: 38935733 DOI: doi:10.1126/science.adm8693 ]
- Antibody 77 fab heavy chain, antibody 77 fab light chain (Complex from Mus musculus)
- Mab 77 light chain (25 kDa, Protein from Homo sapiens)
- Fab 77-stabilized mev f ectodomain fragment (43 kDa, Complex)
- Fusion glycoprotein f0 (57 kDa, Protein from Measles virus strain Ichinose-B95a)
- Measles virus fusion glycoprotein (Complex from Measles virus strain Ichinose-B95a)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mab 77 heavy chain (52 kDa, Protein from Homo sapiens)
Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 7uot
Q-score: 0.559
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ Pubmed: 36288283 DOI: doi:10.1126/scitranslmed.abq0991 ]
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- 8.9f heavy chain (variable domain) (15 kDa, Protein from Homo sapiens)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- Native lassa glycoprotein in complex with 8.9f-scfv and 37.2d-scfv (Complex)
- 8.9f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
Native Lassa glycoprotein in complex with neutralizing antibodies 12.1F and 37.2D
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7uov
Q-score: 0.541
Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, Sullivan B, Smith V, Chukwudozie O, Watanabe R, Robinson JE, Garry RF, Branco LM, Hastie KM, Saphire EO
Sci Transl Med (2022) 14 pp. eabq0991-eabq0991 [ Pubmed: 36288283 DOI: doi:10.1126/scitranslmed.abq0991 ]
- Glycoprotein g2 (26 kDa, Protein from Lassa virus)
- 37.2d light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- 12.1f heavy chain (variable domain) (12 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus)
- 37.2d heavy chain (variable domain) (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 12.1f light chain (variable domain) (11 kDa, Protein from Homo sapiens)
- Native lassa glycoprotein in complex with 12.1f-scfv and 37.2d-scfv (Complex)