Intracellular cryo-tomography structure of EBOV nucleocapsid at 8.9 Angstrom
Resolution: 8.9 Å
EM Method: Subtomogram averaging
Fitted PDBs: 8usn
Q-score: 0.251
Watanabe R, Zyla D, Parekh D, Hong C, Jones Y, Schendel SL, Wan W, Castillon G, Saphire EO
Cell (2024) 187 pp. 5587-5603.e19 [ Pubmed: 39293445 DOI: doi:10.1016/j.cell.2024.08.044 ]
- Complex (Virus)
- Outer np with vp35 np-binding peptide (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Rna (5'-r(*ap*ap*ap*ap*ap*a)-3') (1 kDa, RNA from Zaire)
- Vp24 second layer of nucleocapsid (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Membrane-associated protein vp24 (28 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Nucleoprotein (83 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Np core with rna (Complex from Homo sapiens)
- Vp35 ctd (Complex from Ebola virus - Mayinga, Zaire, 1976)
Watanabe R, Zyla D, Parekh D, Hong C, Jones Y, Schendel SL, Wan W, Castillon G, Saphire EO
Cell (2024) 187 pp. 5587-5603.e19 [ DOI: doi:10.1016/j.cell.2024.08.044 Pubmed: 39293445 ]
Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8dpl
Q-score: 0.536
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ Pubmed: 37938974 DOI: doi:10.1016/j.celrep.2023.113366 ]
- Structure of ebov gp in complex with 2.1.1d5 scfv and 6d6 scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- 2.1.1d5 heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- 2.1.1d5 light chain variable domain (11 kDa, Protein from Homo sapiens)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 6d6 single-chain variable fragment (25 kDa, Protein from Mus musculus)
Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dpm
Q-score: 0.505
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ Pubmed: 37938974 DOI: doi:10.1016/j.celrep.2023.113366 ]
- Complex of ebola virus glycoprotein trimer with 1a2 antibody fab and 6d6 antibody scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 6d6 scfv (25 kDa, Protein from Mus musculus)
- Antibody 9.20.1a2 fab light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody 9.20.1a2 fab (Complex from Homo sapiens)
- Antibody 9.20.1a2 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
Structure of the Inmazeb cocktail and resistance to escape against Ebola virus
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7tn9
Q-score: 0.475
Rayaprolu V, Fulton BO, Rafique A, Arturo E, Williams D, Hariharan C, Callaway H, Parvate A, Schendel SL, Parekh D, Hui S, Shaffer K, Pascal KE, Wloga E, Giordano S, Negron N, Ni M, Copin R, Atwal GS, Franklin M, Boytz RM, Donahue C, Davey R, Baum A, Kyratsous CA, Saphire EO
Cell Host Microbe (2023) 31 pp. 260- [ DOI: doi:10.1016/j.chom.2023.01.002 Pubmed: 36708708 ]
- Inmazeb therapeutic cocktail (Complex)
- Gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Regn3471 light chain (24 kDa, Protein from Mus musculus)
- Regn3470 heavy chain (23 kDa, Protein from Mus musculus)
- Envelope glycoprotein, shed gp (Complex from Mus musculus)
- Regn3479 light chain (23 kDa, Protein from Mus musculus)
- Regn3470 light chain (23 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Regn3471 heavy chain (23 kDa, Protein from Mus musculus)
- Envelope glycoprotein (35 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Regn3479 heavy chain (22 kDa, Protein from Mus musculus)
- Regn3471 heavy chain, regn3479 light chain, regn3471 light chain, regn3479 heavy chain, regn3470 heavy chain, regn3470 light chain (Complex from Ebola virus - Mayinga, Zaire, 1976)