Cryo-EM structure of NRG1A(LRR) in complex with EDS1-SAG101-(ADPr-ATP)
Huang S, Wang J, Song R, Jia A, Xiao Y, Sun Y, Wang L, Mahr D, Wu Z, Han Z, Li X, Parker JE, Chai J
Nature (2025) [ DOI: doi:10.1038/s41586-024-08521-7 ]
- Probable disease resistance protein at5g66900 (46 kDa, Protein from Arabidopsis thaliana)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Protein eds1 (70 kDa, Protein from Arabidopsis thaliana)
- Ternary complex of nrg1a(lrr) with eds1-sag101-(adpr-atp) (Complex from Arabidopsis)
- Senescence-associated carboxylesterase 101 (61 kDa, Protein from Arabidopsis thaliana)
- Adenosine-5'-triphosphate (507 Da, Ligand)
pRib-ADP bound OsEDS1-PAD4-ADR1 complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8zf0
Q-score: 0.443
Wu Y, Xu W, Zhao G, Lei Z, Li K, Liu J, Huang S, Wang J, Zhong X, Yin X, Wang Y, Zhang H, He Y, Ye Z, Meng Y, Chang X, Lin H, Wang X, Gao Y, Chai J, Parker JE, Deng Y, Zhang Y, Gao M, He Z
Science (2024) 386 pp. 1405-1412 [ Pubmed: 39509474 DOI: doi:10.1126/science.adr2138 ]
- Eds1 (68 kDa, Protein from Oryza sativa Japonica Group)
- Rpw8 domain-containing protein (96 kDa, Protein from Oryza sativa Japonica Group)
- [(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-4-[(2s,3r,4s,5r)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate (639 Da, Ligand)
- Lipase-like pad4 (71 kDa, Protein from Oryza sativa Japonica Group)
- Prib-adp bound oseds1-pad4-adr1 complex (Complex from Oryza sativa subsp. japonica)
Cryo-EM structure of EDS1 and SAG101 with ATP-APDR
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 7xjp
Q-score: 0.488
Jia A, Huang S, Song W, Wang J, Meng Y, Sun Y, Xu L, Laessle H, Jirschitzka J, Hou J, Zhang T, Yu W, Hessler G, Li E, Ma S, Yu D, Gebauer J, Baumann U, Liu X, Han Z, Chang J, Parker JE, Chai J
Science (2022) 377 pp. eabq8180-eabq8180 [ Pubmed: 35857644 DOI: doi:10.1126/science.abq8180 ]
- Binary complex of eds1 and sag101 with molecule atp-adpr (Complex from Arabidopsis)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Isopropyl alcohol (60 Da, Ligand)
- Protein eds1 (71 kDa, Protein from Arabidopsis)
- Senescence-associated carboxylesterase 101 (62 kDa, Protein from Arabidopsis)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
Cryo-EM structure of EDS1 and PAD4
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7xdd
Q-score: 0.538
Huang S, Jia A, Song W, Hessler G, Meng Y, Sun Y, Xu L, Laessle H, Jirschitzka J, Ma S, Xiao Y, Yu D, Hou J, Liu R, Sun H, Liu X, Han Z, Chang J, Parker JE, Chai J
Science (2022) 377 pp. eabq3297-eabq3297 [ Pubmed: 35857645 DOI: doi:10.1126/science.abq3297 ]
- Pad4 (Complex from Arabidopsis thaliana)
- Binary complex of eds1 and pad4 (Complex)
- Eds1 (Complex from Arabidopsis thaliana)
- Protein eds1 (71 kDa, Protein from Arabidopsis thaliana)
- Lipase-like pad4 (60 kDa, Protein from Arabidopsis thaliana)
Cryo-EM structure of plant NLR RPP1 LRR-ID domain in complex with ATR1
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 7crb
Q-score: 0.515
Ma S, Lapin D, Liu L, Sun Y, Song W, Zhang X, Logemann E, Yu D, Wang J, Jirschitzka J, Han Z, Schulze-Lefert P, Parker JE, Chai J
Science (2020) 370 [ Pubmed: 33273071 DOI: doi:10.1126/science.abe3069 ]
- Atr1 (Complex from Hyaloperonospora arabidopsidis (strain Emoy2))
- Avirulence protein atr1 (35 kDa, Protein from Hyaloperonospora arabidopsidis (strain Emoy2))
- Local structure of rpp1 lrr-id domain bound with atr1 (Complex)
- Nad+ hydrolase (nadase) (139 kDa, Protein from Arabidopsis thaliana)
- Rpp1 (Complex from Arabidopsis thaliana)
Cryo-EM structure of plant NLR RPP1 tetramer in complex with ATR1
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 7crc
Q-score: 0.469
Ma S, Lapin D, Liu L, Sun Y, Song W, Zhang X, Logemann E, Yu D, Wang J, Jirschitzka J, Han Z, Schulze-Lefert P, Parker JE, Chai J
Science (2020) 370 [ Pubmed: 33273071 DOI: doi:10.1126/science.abe3069 ]
- Tetrameric complex of rpp1 and atr1 (Complex)
- Atr1 (Complex from Hyaloperonospora arabidopsidis (strain Emoy2))
- Avirulence protein atr1 (35 kDa, Protein from Hyaloperonospora arabidopsidis (strain Emoy2))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Nad+ hydrolase (nadase) (139 kDa, Protein from Arabidopsis thaliana)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Rpp1 (Complex from Arabidopsis thaliana)
Cryo-EM map of RPP1 mutant in complex with ATR1
Ma S, Lapin D, Liu L, Sun Y, Song W, Zhang X, Logemann E, Yu D, Wang J, Jirschitzka J, Han Z, Schulze-Lefert P, Parker JE, Chai J
Science (2020) 370 [ Pubmed: 33273071 DOI: doi:10.1126/science.abe3069 ]
Cryo-EM structure of plant NLR RPP1 tetramer core part
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 7dfv
Q-score: 0.549
Ma S, Lapin D, Liu L, Sun Y, Song W, Zhang X, Logemann E, Yu D, Wang J, Jirschitzka J, Han Z, Schulze-Lefert P, Parker JE, Chai J
Science (2020) 370 [ DOI: doi:10.1126/science.abe3069 Pubmed: 33273071 ]