Resolution: 2.9 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ewv
Q-score: 0.447
Sokratian A, Zhou Y, Tatli M, Burbidge KJ, Xu E, Viverette E, Donzelli S, Duda AM, Yuan Y, Li H, Strader S, Patel N, Shiell L, Malankhanova T, Chen O, Mazzulli JR, Perera L, Stahlberg H, Borgnia M, Bartesaghi A, Lashuel HA, West AB
Sci Adv (2024) 10 pp. eadq3539-eadq3539 [ DOI: doi:10.1126/sciadv.adq3539 Pubmed: 39485845 ]
- Alpha-synuclein (14 kDa, Protein from Mus musculus)
- Mouse alpha-synuclein fibrils (10 MDa, Complex from Mus musculus)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7t4q
Q-score: 0.54
Kschonsak M, Johnson MC, Schelling R, Green EM, Rouge L, Ho H, Patel N, Kilic C, Kraft E, Arthur CP, Rohou AL, Comps-Agrar L, Martinez-Martin N, Perez L, Payandeh J, Ciferri C
Sci Adv (2022) 8 pp. eabm2536-eabm2536 [ Pubmed: 35275719 DOI: doi:10.1126/sciadv.abm2536 ]
- Envelope glycoprotein ul130 (28 kDa, Protein from Human betaherpesvirus 5)
- Envelope glycoprotein l (30 kDa, Protein from Human betaherpesvirus 5)
- Envelope glycoprotein h (87 kDa, Protein from Human betaherpesvirus 5)
- Fab 13h11 heavy chain (26 kDa, Protein from Homo sapiens)
- Envelope protein ul131a (15 kDa, Protein from Human betaherpesvirus 5)
- Fab 13h11 light chain (25 kDa, Protein from Homo sapiens)
- Envelope protein ul128 (19 kDa, Protein from Human betaherpesvirus 5)
- Fab 7i13 heavy chain (27 kDa, Protein from Homo sapiens)
- Fab 7i13 light chain (25 kDa, Protein from Homo sapiens)
- Pentameric complex of hcmv proteins gh, gl, ul128, ul130, ul131a bound to fabs of human neutralizing antibodies 2c12, 7i13 and 13h11 (320 kDa, Complex)
- Fab 2c12 heavy chain (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab 2c12 light chain (25 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7t4r
Q-score: 0.429
Kschonsak M, Johnson MC, Schelling R, Green EM, Rouge L, Ho H, Patel N, Kilic C, Kraft E, Arthur CP, Rohou AL, Comps-Agrar L, Martinez-Martin N, Perez L, Payandeh J, Ciferri C
Sci Adv (2022) 8 pp. eabm2536-eabm2536 [ Pubmed: 35275719 DOI: doi:10.1126/sciadv.abm2536 ]
- Envelope glycoprotein ul130 (28 kDa, Protein from Human betaherpesvirus 5)
- Envelope glycoprotein l (30 kDa, Protein from Human betaherpesvirus 5)
- Envelope glycoprotein h (87 kDa, Protein from Human betaherpesvirus 5)
- Fab 13h11 heavy chain (26 kDa, Protein from Homo sapiens)
- Fab msl-109 light chain (28 kDa, Protein from Homo sapiens)
- Complex of 2x hcmv pentamer gh, gl, ul128, ul130, ul131a bound to 1x thbd and 2x fabs of human neutralizing antibodies msl-109 and 13h11 (590 kDa, Complex)
- Envelope protein ul131a (15 kDa, Protein from Human betaherpesvirus 5)
- Fab 13h11 light chain (25 kDa, Protein from Homo sapiens)
- Envelope protein ul128 (19 kDa, Protein from Human betaherpesvirus 5)
- Thrombomodulin (55 kDa, Protein from Homo sapiens)
- Fab msl-109 heavy chain (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7t4s
Q-score: 0.57
Kschonsak M, Johnson MC, Schelling R, Green EM, Rouge L, Ho H, Patel N, Kilic C, Kraft E, Arthur CP, Rohou AL, Comps-Agrar L, Martinez-Martin N, Perez L, Payandeh J, Ciferri C
Sci Adv (2022) 8 pp. eabm2536-eabm2536 [ Pubmed: 35275719 DOI: doi:10.1126/sciadv.abm2536 ]
- Envelope glycoprotein ul130 (28 kDa, Protein from Human betaherpesvirus 5)
- Envelope glycoprotein l (30 kDa, Protein from Human betaherpesvirus 5)
- Envelope glycoprotein h (87 kDa, Protein from Human betaherpesvirus 5)
- Fab 13h11 heavy chain (26 kDa, Protein from Homo sapiens)
- Envelope protein ul131a (15 kDa, Protein from Human betaherpesvirus 5)
- Fab 8i21 heavy chain (26 kDa, Protein from Homo sapiens)
- Neuropilin-2 (98 kDa, Protein from Homo sapiens)
- Fab 8i21 light chain (25 kDa, Protein from Homo sapiens)
- Fab 13h11 light chain (25 kDa, Protein from Homo sapiens)
- Envelope protein ul128 (19 kDa, Protein from Human betaherpesvirus 5)
- Pentameric complex of hcmv proteins gh, gl, ul128, ul130, ul131a bound to neuropilin 2 and fabs of human neutralizing antibodies 8i21 and 13h11 (360 kDa, Complex)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
HBV pgRNA T=4 NCP icosahedral symmetry
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7abl
Q-score: 0.57
Patel N, Clark S, Weiss EU, Mata CP, Bohon J, Farquhar ER, Maskell DP, Ranson NA, Twarock R, Stockley PG
Commun Biol (2021) 4 pp. 1407-1407 [ Pubmed: 34916604 DOI: doi:10.1038/s42003-021-02897-2 ]
- Capsid protein (21 kDa, Protein from Hepatitis B virus)
- Hepatitis b virus (Virus from Hepatitis B virus)
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-1 (120-mer)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7a4f
Q-score: 0.446
Tetter S, Terasaka N, Steinauer A, Bingham RJ, Clark S, Scott AJP, Patel N, Leibundgut M, Wroblewski E, Ban N, Stockley PG, Twarock R, Hilvert D
Science (2021) 372 pp. 1220-1224 [ Pubmed: 34112695 DOI: doi:10.1126/science.abg2822 ]
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-1 (180-mer)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7a4g
Q-score: 0.354
Tetter S, Terasaka N, Steinauer A, Bingham RJ, Clark S, Scott AJP, Patel N, Leibundgut M, Wroblewski E, Ban N, Stockley PG, Twarock R, Hilvert D
Science (2021) 372 pp. 1220-1224 [ Pubmed: 34112695 DOI: doi:10.1126/science.abg2822 ]
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-2 (180-mer)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7a4h
Q-score: 0.29
Tetter S, Terasaka N, Steinauer A, Bingham RJ, Clark S, Scott AJP, Patel N, Leibundgut M, Wroblewski E, Ban N, Stockley PG, Twarock R, Hilvert D
Science (2021) 372 pp. 1220-1224 [ Pubmed: 34112695 DOI: doi:10.1126/science.abg2822 ]
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-3
Resolution: 7.04 Å
EM Method: Single-particle
Fitted PDBs: 7a4i
Q-score: 0.163
Tetter S, Terasaka N, Steinauer A, Bingham RJ, Clark S, Scott AJP, Patel N, Leibundgut M, Wroblewski E, Ban N, Stockley PG, Twarock R, Hilvert D
Science (2021) 372 pp. 1220-1224 [ Pubmed: 34112695 DOI: doi:10.1126/science.abg2822 ]
Aquifex aeolicus lumazine synthase-derived nucleocapsid variant NC-4
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 7a4j
Q-score: 0.518
Tetter S, Terasaka N, Steinauer A, Bingham RJ, Clark S, Scott AJP, Patel N, Leibundgut M, Wroblewski E, Ban N, Stockley PG, Twarock R, Hilvert D
Science (2021) 372 pp. 1220-1224 [ Pubmed: 34112695 DOI: doi:10.1126/science.abg2822 ]