Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8tng
Q-score: 0.402
Xu J, Zhou T, McKee K, Zhang B, Liu C, Nazzari AF, Pegu A, Shen CH, Becker JE, Bender MF, Chan P, Changela A, Chaudhary R, Chen X, Einav T, Kwon YD, Lin BC, Louder MK, Merriam JS, Morano NC, O'Dell S, Olia AS, Rawi R, Roark RS, Stephens T, Teng IT, Tourtellott-Fogt E, Wang S, Yang ES, Shapiro L, Tsybovsky Y, Doria-Rose NA, Casellas R, Kwong PD
Adv Sci (2024) 11 pp. e2309268-e2309268 [ Pubmed: 38704686 DOI: doi:10.1002/advs.202309268 ]
- Envelope glycoproteihiv-1 bg505 ds-sosip gp41n gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cd4-binding site targeting nanobody r27 (12 kDa, Protein from Lama glama)
- Complex between hiv-1 env bg505 ds-sosip and llama nanobody r27 (252 kDa, Complex from Lama glama)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8tnh
Q-score: 0.43
Xu J, Zhou T, McKee K, Zhang B, Liu C, Nazzari AF, Pegu A, Shen CH, Becker JE, Bender MF, Chan P, Changela A, Chaudhary R, Chen X, Einav T, Kwon YD, Lin BC, Louder MK, Merriam JS, Morano NC, O'Dell S, Olia AS, Rawi R, Roark RS, Stephens T, Teng IT, Tourtellott-Fogt E, Wang S, Yang ES, Shapiro L, Tsybovsky Y, Doria-Rose NA, Casellas R, Kwong PD
Adv Sci (2024) 11 pp. e2309268-e2309268 [ Pubmed: 38704686 DOI: doi:10.1002/advs.202309268 ]
- Complex between hiv-1 env bg505 ds-sosip and llama nanobody g36 (252 kDa, Complex from Lama glama)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 bg505 ds-sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cd4-binding site nanobody g36 (13 kDa, Protein from Lama glama)
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8tni
Q-score: 0.391
Xu J, Zhou T, McKee K, Zhang B, Liu C, Nazzari AF, Pegu A, Shen CH, Becker JE, Bender MF, Chan P, Changela A, Chaudhary R, Chen X, Einav T, Kwon YD, Lin BC, Louder MK, Merriam JS, Morano NC, O'Dell S, Olia AS, Rawi R, Roark RS, Stephens T, Teng IT, Tourtellott-Fogt E, Wang S, Yang ES, Shapiro L, Tsybovsky Y, Doria-Rose NA, Casellas R, Kwong PD
Adv Sci (2024) 11 pp. e2309268-e2309268 [ Pubmed: 38704686 DOI: doi:10.1002/advs.202309268 ]
- Heavy chain of bi-specific antibody cap256l-r27 (26 kDa, Protein from Homo sapiens)
- Light chain of bi-specific antibody cap256l-r27 (36 kDa, Protein from Homo sapiens)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex between hiv-1 env bg505 ds-sosip and bi-specific antibody cap256l-r27 (405 kDa, Complex from Homo sapiens)
Structure of Bispecific CAP256V2LS-J3 Fab in complex with BG505 DS-SOSIP.664
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8fis
Q-score: 0.453
Zhang B, Gorman J, Kwon YD, Pegu A, Chao CW, Liu T, Asokan M, Bender MF, Bylund T, Damron L, Gollapudi D, Lei P, Li Y, Liu C, Louder MK, McKee K, Olia AS, Rawi R, Schon A, Wang S, Yang ES, Yang Y, Carlton K, Doria-Rose NA, Shapiro L, Seaman MS, Mascola JR, Kwong PD
MABs (2023) 15 pp. 2165390-2165390 [ Pubmed: 36729903 DOI: doi:10.1080/19420862.2023.2165390 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cap256v2ls-j3-3 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vrc26.25 heavy (26 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- J3-vrc26.25 light (37 kDa, Protein from Lama glama)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7tb8
Q-score: 0.41
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-61.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- The heavy chain of sars-cov-2 antiboddy antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
- The heavy chain of sars-cov-2 antibody a19-61.1 (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The light chain of sars-cov-2 antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (132 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The light chain of sars-cov-2 antibody a19-61.1 (11 kDa, Protein from Homo sapiens)
Locally refined region of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7tbf
Q-score: 0.498
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Light chain of sars-cov-2 antibody a19-61.1 (11 kDa, Protein from Homo sapiens)
- Heavy chain of sars-cov-2 antibody b1-182.1 (24 kDa, Protein from Homo sapiens)
- Heavy chain of sars-cov-2 antibody a19-61.1 (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-61.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain of sars-cov-2 antibody b1-182.1 (23 kDa, Protein from Homo sapiens)
Locally refined region of SARS-CoV-2 spike in complex with antibody A19-46.1
Resolution: 5.08 Å
EM Method: Single-particle
Fitted PDBs: 7tc9
Q-score: 0.221
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Homo sapiens)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibody a19-46.1, local refinement. (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibody A19-46.1
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7tca
Q-score: 0.282
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with antibody a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 7tcc
Q-score: 0.268
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Heavy chain of antibody a19-46.1 (14 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of antibody a19-46.1 (11 kDa, Protein from Homo sapiens)
- Heavy chain of antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7u0d
Q-score: 0.236
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Light chain of sars-cov-2 antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- Heavy chain of sars-cov-2 antibody b1-182.1 (24 kDa, Protein from Homo sapiens)
- Surface glycoprotein (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of sars-cov-2 antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of sars-cov-2 antibody b1-182.1 (23 kDa, Protein from Homo sapiens)
- Ternary complex of sars-cov-2 omicron rbd in complex with antibodies b1-182.1 and a19-46.1 (Complex from Homo sapiens)