Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8tng
Q-score: 0.402
Xu J, Zhou T, McKee K, Zhang B, Liu C, Nazzari AF, Pegu A, Shen CH, Becker JE, Bender MF, Chan P, Changela A, Chaudhary R, Chen X, Einav T, Kwon YD, Lin BC, Louder MK, Merriam JS, Morano NC, O'Dell S, Olia AS, Rawi R, Roark RS, Stephens T, Teng IT, Tourtellott-Fogt E, Wang S, Yang ES, Shapiro L, Tsybovsky Y, Doria-Rose NA, Casellas R, Kwong PD
Adv Sci (2024) 11 pp. e2309268-e2309268 [ Pubmed: 38704686 DOI: doi:10.1002/advs.202309268 ]
- Envelope glycoproteihiv-1 bg505 ds-sosip gp41n gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cd4-binding site targeting nanobody r27 (12 kDa, Protein from Lama glama)
- Complex between hiv-1 env bg505 ds-sosip and llama nanobody r27 (252 kDa, Complex from Lama glama)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8tnh
Q-score: 0.43
Xu J, Zhou T, McKee K, Zhang B, Liu C, Nazzari AF, Pegu A, Shen CH, Becker JE, Bender MF, Chan P, Changela A, Chaudhary R, Chen X, Einav T, Kwon YD, Lin BC, Louder MK, Merriam JS, Morano NC, O'Dell S, Olia AS, Rawi R, Roark RS, Stephens T, Teng IT, Tourtellott-Fogt E, Wang S, Yang ES, Shapiro L, Tsybovsky Y, Doria-Rose NA, Casellas R, Kwong PD
Adv Sci (2024) 11 pp. e2309268-e2309268 [ Pubmed: 38704686 DOI: doi:10.1002/advs.202309268 ]
- Complex between hiv-1 env bg505 ds-sosip and llama nanobody g36 (252 kDa, Complex from Lama glama)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 bg505 ds-sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cd4-binding site nanobody g36 (13 kDa, Protein from Lama glama)
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8tni
Q-score: 0.391
Xu J, Zhou T, McKee K, Zhang B, Liu C, Nazzari AF, Pegu A, Shen CH, Becker JE, Bender MF, Chan P, Changela A, Chaudhary R, Chen X, Einav T, Kwon YD, Lin BC, Louder MK, Merriam JS, Morano NC, O'Dell S, Olia AS, Rawi R, Roark RS, Stephens T, Teng IT, Tourtellott-Fogt E, Wang S, Yang ES, Shapiro L, Tsybovsky Y, Doria-Rose NA, Casellas R, Kwong PD
Adv Sci (2024) 11 pp. e2309268-e2309268 [ Pubmed: 38704686 DOI: doi:10.1002/advs.202309268 ]
- Heavy chain of bi-specific antibody cap256l-r27 (26 kDa, Protein from Homo sapiens)
- Light chain of bi-specific antibody cap256l-r27 (36 kDa, Protein from Homo sapiens)
- Hiv-1 bg505 ds-sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 bg505 ds-sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex between hiv-1 env bg505 ds-sosip and bi-specific antibody cap256l-r27 (405 kDa, Complex from Homo sapiens)
Structure of Bispecific CAP256V2LS-J3 Fab in complex with BG505 DS-SOSIP.664
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8fis
Q-score: 0.453
Zhang B, Gorman J, Kwon YD, Pegu A, Chao CW, Liu T, Asokan M, Bender MF, Bylund T, Damron L, Gollapudi D, Lei P, Li Y, Liu C, Louder MK, McKee K, Olia AS, Rawi R, Schon A, Wang S, Yang ES, Yang Y, Carlton K, Doria-Rose NA, Shapiro L, Seaman MS, Mascola JR, Kwong PD
MABs (2023) 15 pp. 2165390-2165390 [ Pubmed: 36729903 DOI: doi:10.1080/19420862.2023.2165390 ]
- Vrc26.25 heavy (26 kDa, Protein from Homo sapiens)
- J3-vrc26.25 light (37 kDa, Protein from Lama glama)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Cap256v2ls-j3-3 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 6vi0
Q-score: 0.502
Kwon YD, Asokan M, Gorman J, Zhang B, Liu Q, Louder MK, Lin BC, McKee K, Pegu A, Verardi R, Yang ES, Program VP, Carlton K, Doria-Rose NA, Lusso P, Mascola JR, Kwong PD
MABs () 13 pp. 1946918-1946918 [ DOI: doi:10.1080/19420862.2021.1946918 Pubmed: 34328065 ]
- Bg505 ds.sosip with antibody vrc01.23 fab (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vrc01.23 light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vrc01.23 heavy chain (25 kDa, Protein from Homo sapiens)
- Bg505 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 env bg505 ds-sosip and antibodies vrc01.23 (Complex)