Atomic structure and conformational variability of the HER2-trastuzumab-pertuzumab complex
Ruedas R, Vuillemot R, Tubiana T, Winter JM, Pieri L, Arteni AA, Samson C, Jonic S, Mathieu M, Bressanelli S
J Struct Biol (2024) 216 [ Pubmed: 38723875 DOI: 10.1016/j.jsb.2024.108095 ]
Image sets:
Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8pwh
Q-score: 0.417
Ruedas R, Vuillemot R, Tubiana T, Winter JM, Pieri L, Arteni AA, Samson C, Jonic S, Mathieu M, Bressanelli S
J Struct Biol (2024) 216 pp. 108095-108095 [ DOI: doi:10.1016/j.jsb.2024.108095 Pubmed: 38723875 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ternary complex of her2-trastuzumab-pertuzumab fabs (171 kDa, Complex from Homo sapiens)
- Pertuzumab fab light chain (23 kDa, Protein from Homo sapiens)
- Trastuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Pertuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Trastuzumab fab light chain (23 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (68 kDa, Protein from Homo sapiens)
Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8q6j
Q-score: 0.364
Ruedas R, Vuillemot R, Tubiana T, Winter JM, Pieri L, Arteni AA, Samson C, Jonic S, Mathieu M, Bressanelli S
J Struct Biol (2024) 216 pp. 108095-108095 [ DOI: doi:10.1016/j.jsb.2024.108095 Pubmed: 38723875 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ternary complex of her2-trastuzumab-pertuzumab fabs (171 kDa, Complex from Homo sapiens)
- Pertuzumab fab light chain (23 kDa, Protein from Homo sapiens)
- Trastuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Pertuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Receptor tyrosine-protein kinase erbb-2 (68 kDa, Protein from Homo sapiens)
- Trastuzumab fab light chain (23 kDa, Protein from Homo sapiens)
Ruedas R, Vuillemot R, Tubiana T, Winter JM, Pieri L, Arteni AA, Samson C, Jonic J, Mathieu M, Bressanelli S
To Be Published
- Pertuzumab light chain (Protein from Homo sapiens)
- Receptor tyrosine-protein kinase her2 (Protein from Homo sapiens)
- Ternary complex of her2-trastuzumab-pertuzumab fabs (171 kDa, Complex from Homo sapiens)
- Pertuzumab fab heavy chain (Protein from Homo sapiens)
Ruedas R, Vuillemot R, Tubiana T, Winter JM, Pieri L, Arteni AA, Samson C, Jonic J, Mathieu M, Bressanelli S
To Be Published
Atomic structure of Lanreotide nanotubes revealed by cryo-EM
Pieri L, Wang F, Arteni AA, Vos M, Winter JM, Le Du MH, Artzner F, Gobeaux F, Legrand P, Boulard Y, Bressanelli S, Egelman EH, Paternostre M
Proc Natl Acad Sci U S A (2022) 119 [ Pubmed: 35042822 DOI: 10.1073/pnas.2120346119 ]
Image sets:
Resolution: 2.46 Å
EM Method: Helical reconstruction
Fitted PDBs: 7q5a
Q-score: 0.685
Pieri L, Wang F, Arteni AA, Vos M, Winter JM, Le Du MH, Artzner F, Gobeaux F, Legrand P, Boulard Y, Bressanelli S, Egelman EH, Paternostre M
PNAS (2022) 119 [ Pubmed: 35042822 DOI: doi:10.1073/pnas.2120346119 ]
- Lanreotide (1 MDa, Complex from Homo sapiens)
- Lanreotide (1 kDa, Protein from Homo sapiens)