cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8c8t
Q-score: 0.511
Molinos-Albert LM, Baquero E, Bouvin-Pley M, Lorin V, Charre C, Planchais C, Dimitrov JD, Monceaux V, Vos M, Hocqueloux L, Berger JL, Seaman MS, Braibant M, Avettand-Fenoel V, Saez-Cirion A, Mouquet H
Cell Host Microbe (2023) 31 pp. 1275- [ DOI: doi:10.1016/j.chom.2023.06.006 Pubmed: 37433296 ]
- Envelope glycoprotein gp160 (52 kDa, Protein from Human immunodeficiency virus 1)
- Igg 3bnc117 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg eptc112 fab fragment heavy chain (25 kDa, Protein from Homo sapiens)
- Gp41 bg505 t332n sosip.664 (16 kDa, Protein from Human immunodeficiency virus 1)
- Ternary complex of bg505 sosip.664 hiv-1 env with bnabs eptc112 and 3bnc117 (Complex from Homo sapiens)
- Igg eptc112 fab light chain (22 kDa, Protein from Homo sapiens)
- Igg 3bnc117 fab heavy chain (24 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike in complex with the neutralizing antibody Cv2.1169
Planchais C, Fernandez I, Bruel T, de Melo GD, Prot M, Beretta M, Guardado-Calvo P, Dufloo J, Molinos-Albert LM, Backovic M, Chiaravalli J, Giraud E, Vesin B, Conquet L, Grzelak L, Planas D, Staropoli I, Guivel-Benhassine F, Hieu T, Boulle M, Cervantes-Gonzalez M, Ungeheuer MN, Charneau P, van der Werf S, Agou F, Dimitrov JD, Simon-Loriere E, Bourhy H, Montagutelli X, Rey FA, Schwartz O, Mouquet H
J Exp Med (2022) 219 [ DOI: doi:10.1084/jem.20220638 Pubmed: 35704748 ]
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7s6i
Q-score: 0.514
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB
PNAS (2022) 119 pp. e2120976119-e2120976119 [ DOI: doi:10.1073/pnas.2120976119 Pubmed: 35549549 ]
J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (conformation 3)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7s6j
Q-score: 0.376
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB
PNAS (2022) 119 pp. e2120976119-e2120976119 [ DOI: doi:10.1073/pnas.2120976119 Pubmed: 35549549 ]
- J08 fragment antigen binding heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- J08 fragment antigen binding light chain variable domain (11 kDa, Protein from Homo sapiens)
- J08 fragment antigen binding in complex with sars-2-cov-6p-mut2 s protein (690 kDa, Complex)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 2)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7s6k
Q-score: 0.416
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB
PNAS (2022) 119 pp. e2120976119-e2120976119 [ DOI: doi:10.1073/pnas.2120976119 Pubmed: 35549549 ]
- J08 fragment antigen binding heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- J08 fragment antigen binding light chain variable domain (11 kDa, Protein from Homo sapiens)
- J08 fragment antigen binding in complex with sars-2-cov-6p-mut2 s protein (690 kDa, Complex)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (conformation 3)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7s6l
Q-score: 0.299
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB
PNAS (2022) 119 pp. e2120976119-e2120976119 [ Pubmed: 35549549 DOI: doi:10.1073/pnas.2120976119 ]
- J08 fragment antigen binding in complex with sars-2-cov-6p-mut7 s protein (590 kDa, Complex)
- J08 fragment antigen binding light chain variable domain (11 kDa, Protein from Homo sapiens)
- J08 fragment antigen binding heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
J08 fragment antigen binding in complex with Omicron SARS-CoV-2-6P S protein
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB
PNAS (2022) 119 pp. e2120976119-e2120976119 [ DOI: doi:10.1073/pnas.2120976119 Pubmed: 35549549 ]
- J08 fragment antigen binding light chain variable domain (Macromolecule from Homo sapiens)
- J08 fragment antigen binding heavy chain variable domain (Macromolecule from Homo sapiens)
- Omicron sars-cov-2-6p s protein (Macromolecule from Severe acute respiratory syndrome coronavirus 2)
- J08 fragment antigen binding in complex with omicron sars-cov-2-6p s protein (Complex from Severe acute respiratory syndrome coronavirus 2)
HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117.
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7pc2
Q-score: -0.058
Lorin V, Fernandez I, Masse-Ranson G, Bouvin-Pley M, Molinos-Albert LM, Planchais C, Hieu T, Pehau-Arnaudet G, Hrebik D, Girelli-Zubani G, Fiquet O, Guivel-Benhassine F, Sanders RW, Walker BD, Schwartz O, Scheid JF, Dimitrov JD, Plevka P, Braibant M, Seaman MS, Bontems F, Di Santo JP, Rey FA, Mouquet H
J Exp Med (2022) 219 [ Pubmed: 35230385 DOI: doi:10.1084/jem.20212045 ]
- 3bnc117 igg fab light chain (23 kDa, Protein from Homo sapiens)
- Env protomer with one 3bnc117 fab and one 7-269 fab (Complex from Homo sapiens)
- 7-269 iga fab light chain (23 kDa, Protein from Homo sapiens)
- Ternary complex of hiv env (bg505 sosip.664) with bnabs 3bnc117 (igg fab) and 7269 (iga fab) (Complex from Homo sapiens)
- Gp120, bg505 sosip.664 t332n (54 kDa, Protein from Human immunodeficiency virus)
- 3bnc igg fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gp41 bg505 t332n sosip.664 (17 kDa, Protein from Human immunodeficiency virus)
- 7-269 iga fab heavy chain (26 kDa, Protein from Homo sapiens)
HIV-1 Env (BG505 SOSIP.664) in complex with the bNAb 7-176
Lorin V, Fernandez I, Masse-Ranson G, Bouvin-Pley M, Molinos-Albert LM, Planchais C, Hieu T, Pehau-Arnaudet G, Hrebik D, Girelli-Zubani G, Fiquet O, Guivel-Benhassine F, Sanders RW, Walker BD, Schwartz O, Scheid JF, Dimitrov JD, Plevka P, Braibant M, Seaman MS, Bontems F, Di Santo JP, Rey FA, Mouquet H
J Exp Med (2022) 219 [ DOI: doi:10.1084/jem.20212045 Pubmed: 35230385 ]