cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8c8t
Q-score: 0.511
Molinos-Albert LM, Baquero E, Bouvin-Pley M, Lorin V, Charre C, Planchais C, Dimitrov JD, Monceaux V, Vos M, Hocqueloux L, Berger JL, Seaman MS, Braibant M, Avettand-Fenoel V, Saez-Cirion A, Mouquet H
Cell Host Microbe (2023) 31 pp. 1275- [ DOI: doi:10.1016/j.chom.2023.06.006 Pubmed: 37433296 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg 3bnc117 fab light chain (23 kDa, Protein from Homo sapiens)
- Ternary complex of bg505 sosip.664 hiv-1 env with bnabs eptc112 and 3bnc117 (Complex from Homo sapiens)
- Envelope glycoprotein gp160 (52 kDa, Protein from Human immunodeficiency virus 1)
- Gp41 bg505 t332n sosip.664 (16 kDa, Protein from Human immunodeficiency virus 1)
- Igg 3bnc117 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Igg eptc112 fab light chain (22 kDa, Protein from Homo sapiens)
- Igg eptc112 fab fragment heavy chain (25 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike in complex with the neutralizing antibody Cv2.1169
Planchais C, Fernandez I, Bruel T, de Melo GD, Prot M, Beretta M, Guardado-Calvo P, Dufloo J, Molinos-Albert LM, Backovic M, Chiaravalli J, Giraud E, Vesin B, Conquet L, Grzelak L, Planas D, Staropoli I, Guivel-Benhassine F, Hieu T, Boulle M, Cervantes-Gonzalez M, Ungeheuer MN, Charneau P, van der Werf S, Agou F, Dimitrov JD, Simon-Loriere E, Bourhy H, Montagutelli X, Rey FA, Schwartz O, Mouquet H
J Exp Med (2022) 219 [ Pubmed: 35704748 DOI: doi:10.1084/jem.20220638 ]
HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117.
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7pc2
Q-score: -0.058
Lorin V, Fernandez I, Masse-Ranson G, Bouvin-Pley M, Molinos-Albert LM, Planchais C, Hieu T, Pehau-Arnaudet G, Hrebik D, Girelli-Zubani G, Fiquet O, Guivel-Benhassine F, Sanders RW, Walker BD, Schwartz O, Scheid JF, Dimitrov JD, Plevka P, Braibant M, Seaman MS, Bontems F, Di Santo JP, Rey FA, Mouquet H
J Exp Med (2022) 219 [ Pubmed: 35230385 DOI: doi:10.1084/jem.20212045 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gp120, bg505 sosip.664 t332n (54 kDa, Protein from Human immunodeficiency virus)
- Gp41 bg505 t332n sosip.664 (17 kDa, Protein from Human immunodeficiency virus)
- 3bnc117 igg fab light chain (23 kDa, Protein from Homo sapiens)
- 3bnc igg fab heavy chain (24 kDa, Protein from Homo sapiens)
- 7-269 iga fab light chain (23 kDa, Protein from Homo sapiens)
- Ternary complex of hiv env (bg505 sosip.664) with bnabs 3bnc117 (igg fab) and 7269 (iga fab) (Complex from Homo sapiens)
- 7-269 iga fab heavy chain (26 kDa, Protein from Homo sapiens)
- Env protomer with one 3bnc117 fab and one 7-269 fab (Complex from Homo sapiens)
HIV-1 Env (BG505 SOSIP.664) in complex with the bNAb 7-176
Lorin V, Fernandez I, Masse-Ranson G, Bouvin-Pley M, Molinos-Albert LM, Planchais C, Hieu T, Pehau-Arnaudet G, Hrebik D, Girelli-Zubani G, Fiquet O, Guivel-Benhassine F, Sanders RW, Walker BD, Schwartz O, Scheid JF, Dimitrov JD, Plevka P, Braibant M, Seaman MS, Bontems F, Di Santo JP, Rey FA, Mouquet H
J Exp Med (2022) 219 [ Pubmed: 35230385 DOI: doi:10.1084/jem.20212045 ]
HIV-1 Env (BG505 SOSIP.664) in complex with the bNAb 7-155
Lorin V, Fernandez I, Masse-Ranson G, Bouvin-Pley M, Molinos-Albert LM, Planchais C, Hieu T, Pehau-Arnaudet G, Hrebik D, Girelli-Zubani G, Fiquet O, Guivel-Benhassine F, Sanders RW, Walker BD, Schwartz O, Scheid JF, Dimitrov JD, Plevka P, Braibant M, Seaman MS, Bontems F, Di Santo JP, Rey FA, Mouquet H
J Exp Med (2022) 219 [ Pubmed: 35230385 DOI: doi:10.1084/jem.20212045 ]