cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8c8t
Q-score: 0.511
Molinos-Albert LM, Baquero E, Bouvin-Pley M, Lorin V, Charre C, Planchais C, Dimitrov JD, Monceaux V, Vos M, Hocqueloux L, Berger JL, Seaman MS, Braibant M, Avettand-Fenoel V, Saez-Cirion A, Mouquet H
Cell Host Microbe (2023) 31 pp. 1275- [ Pubmed: 37433296 DOI: doi:10.1016/j.chom.2023.06.006 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg eptc112 fab fragment heavy chain (25 kDa, Protein from Homo sapiens)
- Gp41 bg505 t332n sosip.664 (16 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (52 kDa, Protein from Human immunodeficiency virus 1)
- Ternary complex of bg505 sosip.664 hiv-1 env with bnabs eptc112 and 3bnc117 (Complex from Homo sapiens)
- Igg 3bnc117 fab light chain (23 kDa, Protein from Homo sapiens)
- Igg 3bnc117 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Igg eptc112 fab light chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7s6i
Q-score: 0.514
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB
PNAS (2022) 119 pp. e2120976119-e2120976119 [ DOI: doi:10.1073/pnas.2120976119 Pubmed: 35549549 ]
J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (conformation 3)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7s6j
Q-score: 0.376
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB
PNAS (2022) 119 pp. e2120976119-e2120976119 [ DOI: doi:10.1073/pnas.2120976119 Pubmed: 35549549 ]
- J08 fragment antigen binding light chain variable domain (11 kDa, Protein from Homo sapiens)
- J08 fragment antigen binding heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- J08 fragment antigen binding in complex with sars-2-cov-6p-mut2 s protein (690 kDa, Complex)
J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut2 S protein (conformation 2)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7s6k
Q-score: 0.416
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB
PNAS (2022) 119 pp. e2120976119-e2120976119 [ DOI: doi:10.1073/pnas.2120976119 Pubmed: 35549549 ]
- J08 fragment antigen binding light chain variable domain (11 kDa, Protein from Homo sapiens)
- J08 fragment antigen binding heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- J08 fragment antigen binding in complex with sars-2-cov-6p-mut2 s protein (690 kDa, Complex)
J08 fragment antigen binding in complex with SARS-CoV-2-6P-Mut7 S protein (conformation 3)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7s6l
Q-score: 0.299
Torres JL, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, Donnici L, Conti M, Planchais C, Planas D, Manganaro N, Pantano E, Paciello I, Pileri P, Bruel T, Montomoli E, Mouquet H, Schwartz O, Sala C, De Francesco R, Wilson IA, Rappuoli R, Ward AB
PNAS (2022) 119 pp. e2120976119-e2120976119 [ DOI: doi:10.1073/pnas.2120976119 Pubmed: 35549549 ]
- J08 fragment antigen binding light chain variable domain (11 kDa, Protein from Homo sapiens)
- J08 fragment antigen binding in complex with sars-2-cov-6p-mut7 s protein (590 kDa, Complex)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- J08 fragment antigen binding heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
HIV-1 Env (BG505 SOSIP.664) in complex with the IgA bNAb 7-269 and the antibody 3BNC117.
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7pc2
Q-score: -0.058
Lorin V, Fernandez I, Masse-Ranson G, Bouvin-Pley M, Molinos-Albert LM, Planchais C, Hieu T, Pehau-Arnaudet G, Hrebik D, Girelli-Zubani G, Fiquet O, Guivel-Benhassine F, Sanders RW, Walker BD, Schwartz O, Scheid JF, Dimitrov JD, Plevka P, Braibant M, Seaman MS, Bontems F, Di Santo JP, Rey FA, Mouquet H
J Exp Med (2022) 219 [ Pubmed: 35230385 DOI: doi:10.1084/jem.20212045 ]
- 7-269 iga fab heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gp41 bg505 t332n sosip.664 (17 kDa, Protein from Human immunodeficiency virus)
- 3bnc117 igg fab light chain (23 kDa, Protein from Homo sapiens)
- 7-269 iga fab light chain (23 kDa, Protein from Homo sapiens)
- Env protomer with one 3bnc117 fab and one 7-269 fab (Complex from Homo sapiens)
- Gp120, bg505 sosip.664 t332n (54 kDa, Protein from Human immunodeficiency virus)
- 3bnc igg fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ternary complex of hiv env (bg505 sosip.664) with bnabs 3bnc117 (igg fab) and 7269 (iga fab) (Complex from Homo sapiens)
Structure of full-length CD20 in complex with Rituximab Fab
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 6y90
Q-score: 0.365
Kumar A, Planchais C, Fronzes R, Mouquet H, Reyes N
Science (2020) 369 pp. 793-799 [ DOI: doi:10.1126/science.abb8008 Pubmed: 32792392 ]
- Rituximab fab heavy chain (23 kDa, Protein from Mus musculus)
- Full-length human antigen cd20 in complex with rituximab fab (Complex)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Full-length human cd20 (Complex from Homo sapiens)
- B-lymphocyte antigen cd20 (19 kDa, Protein from Homo sapiens)
- Pentadecane (212 Da, Ligand)
- Rituximab fab light chain (23 kDa, Protein from Mus musculus)
- Rituximab fab (Complex from Mus musculus)
Structure of full-length CD20 in complex with Ofatumumab Fab
Resolution: 4.73 Å
EM Method: Single-particle
Fitted PDBs: 6y92
Q-score: 0.302
Kumar A, Planchais C, Fronzes R, Mouquet H, Reyes N
Science (2020) 369 pp. 793-799 [ DOI: doi:10.1126/science.abb8008 Pubmed: 32792392 ]
- Ofatumumab fab light chain (23 kDa, Protein from Homo sapiens)
- Ofatumumab fab heavy chain (23 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- B-lymphocyte antigen cd20 (19 kDa, Protein from Homo sapiens)
- Full-length human antigen cd20 in complex with ofatumumab fab (Complex)
- Full-length human cd20 (Complex from Homo sapiens)
- Ofatumumab fab (Complex from Homo sapiens)
Structure of full-length CD20 in complex with Obinutuzumab Fab
Resolution: 4.33 Å
EM Method: Single-particle
Fitted PDBs: 6y97
Q-score: 0.257
Kumar A, Planchais C, Fronzes R, Mouquet H, Reyes N
Science (2020) 369 pp. 793-799 [ DOI: doi:10.1126/science.abb8008 Pubmed: 32792392 ]
- Obinutuzumab fab (Cellular component from Homo sapiens)
- Full-length human antigen cd20 in complex with obinutuzumab fab (Cell from Homo sapiens)
- B-lymphocyte antigen cd20 (18 kDa, Protein from Homo sapiens)
- Obinutuzumab fab light chain (11 kDa, Protein from Homo sapiens)
- Obinutuzumab fab heavy chain (12 kDa, Protein from Homo sapiens)
- Full-length human cd20 (Cellular component from Homo sapiens)
Structure of full-length CD20 in complex with Ofatumumab Fab
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6y9a
Q-score: 0.205
Kumar A, Planchais C, Fronzes R, Mouquet H, Reyes N
Science (2020) 369 pp. 793-799 [ DOI: doi:10.1126/science.abb8008 Pubmed: 32792392 ]
- Full-length human antigen cd20 in complex with obinutuzumab (Complex)
- Obinutuzumab fab (Complex from Homo sapiens)
- B-lymphocyte antigen cd20 (18 kDa, Protein from Homo sapiens)
- Obinutuzumab fab light chain (23 kDa, Protein from Homo sapiens)
- Full-length human cd20 (Complex from Homo sapiens)
- Obinutuzumab fab heavy chain (23 kDa, Protein from Homo sapiens)