Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 7txd
Q-score: 0.352
Glogl M, Friedrich N, Cerutti G, Lemmin T, Kwon YD, Gorman J, Maliqi L, Mittl PRE, Hesselman MC, Schmidt D, Weber J, Foulkes C, Dingens AS, Bylund T, Olia AS, Verardi R, Reinberg T, Baumann NS, Rusert P, Dreier B, Shapiro L, Kwong PD, Pluckthun A, Trkola A
Nat Struct Mol Biol (2023) 30 pp. 1323-1336 [ DOI: doi:10.1038/s41594-023-01062-z Pubmed: 37605043 ]
- Bg505 sosip hiv-1 env trimer in complex with cd4 receptor (d1d2) and broadly neutralizing darpin bnd.9 (Complex from Human immunodeficiency virus 1)
- T-cell surface glycoprotein cd4 (20 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Broadly neutralizing darpin bnd.9 (21 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7qvm
Q-score: 0.423
Waltenspuhl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Pluckthun A
Nat Commun (2022) 13 pp. 4153-4153 [ DOI: doi:10.1038/s41467-022-31325-0 Pubmed: 35851571 ]
- Otr in complex with oxytocin, heterotrimeric mini-gq chimera (goqi) and scfv16 (Complex)
- Heterotrimeric mini-gq chimera (goqi) and oxytocin receptor (Complex from Homo sapiens)
- Oxytocin (1 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Antibody fragment scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Oxytocin receptor (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha,cdna flj31446 fis, clone nt2ne2000909, highly similar to guanine nucleotide-binding protein g(o) subunit alpha 1 (25 kDa, Protein from Homo sapiens)
- Oxytocin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7pdf
Q-score: 0.445
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Magnesium ion (24 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
- Adenylyl cyclase 9 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (47 kDa, Protein from Bos taurus)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- 5'-guanosine-diphosphate-monothiophosphate (539 Da, Ligand)
structure of Adenylyl cyclase 9 in complex with MANT-GTP
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 7pd4
Q-score: 0.211
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex from Bos taurus)
Structure of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7pd8
Q-score: 0.339
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Adenylate cyclase 9 (Complex from Bos taurus)
- Darpin c4 (16 kDa, Protein from synthetic construct)
- Darpin c4 (Complex from synthetic construct)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
Focus refinement of soluble domain of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7pdd
Q-score: 0.308
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Adenylate cyclase 9 (Complex from Bos taurus)
- Darpin c4 (16 kDa, Protein from synthetic construct)
- Darpin c4 (Complex from synthetic construct)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
Structure of Adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7pde
Q-score: 0.288
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Adenylate cyclase 9 (Complex from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (47 kDa, Protein from Bos taurus)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- 5'-guanosine-diphosphate-monothiophosphate (539 Da, Ligand)
structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7pdg
Q-score: 0.313
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Adenylate cyclase 9 (Complex from Bos taurus)
- Darpin c4 (16 kDa, Protein from synthetic construct)
- Darpin c4 (Complex from synthetic construct)
- Adenylyl cyclase 9 in complex with darpin c4 and atp-as (Complex)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7pdh
Q-score: 0.325
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Adenylate cyclase 9 (Complex from Bos taurus)
- Darpin c4 (16 kDa, Protein from synthetic construct)
- Darpin c4 (Complex from synthetic construct)
- Adenylyl cyclase 9 in complex with darpin c4 and atp-as (Complex)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 7p00
Q-score: 0.546
Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A
Sci Adv (2021) 7 pp. eabk2872-eabk2872 [ Pubmed: 34878828 DOI: doi:10.1126/sciadv.abk2872 ]
- Substance p (1 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (32 kDa, Protein from Mus musculus)
- Substance-p receptor (44 kDa, Protein from Homo sapiens)
- Nk1r in complex with substance p, heterotrimeric mini-gq chimera (gsqi) and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)