Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 7txd
Q-score: 0.352
Glogl M, Friedrich N, Cerutti G, Lemmin T, Kwon YD, Gorman J, Maliqi L, Mittl PRE, Hesselman MC, Schmidt D, Weber J, Foulkes C, Dingens AS, Bylund T, Olia AS, Verardi R, Reinberg T, Baumann NS, Rusert P, Dreier B, Shapiro L, Kwong PD, Pluckthun A, Trkola A
Nat Struct Mol Biol (2023) 30 pp. 1323-1336 [ Pubmed: 37605043 DOI: doi:10.1038/s41594-023-01062-z ]
- Bg505 sosip hiv-1 env trimer in complex with cd4 receptor (d1d2) and broadly neutralizing darpin bnd.9 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Broadly neutralizing darpin bnd.9 (21 kDa, Protein from synthetic construct)
- T-cell surface glycoprotein cd4 (20 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7qvm
Q-score: 0.423
Waltenspuhl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Pluckthun A
Nat Commun (2022) 13 pp. 4153-4153 [ DOI: doi:10.1038/s41467-022-31325-0 Pubmed: 35851571 ]
- Oxytocin (1 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha,cdna flj31446 fis, clone nt2ne2000909, highly similar to guanine nucleotide-binding protein g(o) subunit alpha 1 (25 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Heterotrimeric mini-gq chimera (goqi) and oxytocin receptor (Complex from Homo sapiens)
- Oxytocin receptor (39 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Otr in complex with oxytocin, heterotrimeric mini-gq chimera (goqi) and scfv16 (Complex)
- Oxytocin (Complex from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7pdf
Q-score: 0.445
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ Pubmed: 35210418 DOI: doi:10.1038/s41467-022-28685-y ]
- Magnesium ion (24 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (47 kDa, Protein from Bos taurus)
- 5'-guanosine-diphosphate-monothiophosphate (539 Da, Ligand)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylyl cyclase 9 (Complex from Bos taurus)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
structure of Adenylyl cyclase 9 in complex with MANT-GTP
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 7pd4
Q-score: 0.211
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ Pubmed: 35210418 DOI: doi:10.1038/s41467-022-28685-y ]
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex from Bos taurus)
Structure of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7pd8
Q-score: 0.339
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ Pubmed: 35210418 DOI: doi:10.1038/s41467-022-28685-y ]
- Darpin c4 (Complex from synthetic construct)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Adenylate cyclase 9 (Complex from Bos taurus)
- Darpin c4 (16 kDa, Protein from synthetic construct)
Focus refinement of soluble domain of Adenylyl cyclase 9 in complex with DARPin C4 and MANT-GTP
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7pdd
Q-score: 0.308
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ Pubmed: 35210418 DOI: doi:10.1038/s41467-022-28685-y ]
- Darpin c4 (Complex from synthetic construct)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Adenylate cyclase 9 (Complex from Bos taurus)
- Darpin c4 (16 kDa, Protein from synthetic construct)
Structure of Adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7pde
Q-score: 0.288
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ Pubmed: 35210418 DOI: doi:10.1038/s41467-022-28685-y ]
- Magnesium ion (24 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (47 kDa, Protein from Bos taurus)
- 5'-guanosine-diphosphate-monothiophosphate (539 Da, Ligand)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
- Adenylate cyclase 9 (Complex from Bos taurus)
structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7pdg
Q-score: 0.313
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ Pubmed: 35210418 DOI: doi:10.1038/s41467-022-28685-y ]
- Adenylyl cyclase 9 in complex with darpin c4 and atp-as (Complex)
- Darpin c4 (Complex from synthetic construct)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylate cyclase 9 (Complex from Bos taurus)
- Darpin c4 (16 kDa, Protein from synthetic construct)
structure of adenylyl cyclase 9 in complex with DARPin C4 and ATP-aS
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7pdh
Q-score: 0.325
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ Pubmed: 35210418 DOI: doi:10.1038/s41467-022-28685-y ]
- Adenylyl cyclase 9 in complex with darpin c4 and atp-as (Complex)
- Darpin c4 (Complex from synthetic construct)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylate cyclase 9 (Complex from Bos taurus)
- Darpin c4 (16 kDa, Protein from synthetic construct)
Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 7p00
Q-score: 0.546
Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A
Sci Adv (2021) 7 pp. eabk2872-eabk2872 [ DOI: doi:10.1126/sciadv.abk2872 Pubmed: 34878828 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Substance p (1 kDa, Protein from Homo sapiens)
- Substance-p receptor (44 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nk1r in complex with substance p, heterotrimeric mini-gq chimera (gsqi) and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)