Structure of Adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7pde
Q-score: 0.288
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Magnesium ion (24 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (47 kDa, Protein from Bos taurus)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
- 5'-guanosine-diphosphate-monothiophosphate (539 Da, Ligand)
- Adenylate cyclase 9 (Complex from Bos taurus)
Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, AHD and nanodisc mask out
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7l0p
Q-score: 0.404
Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G
Nat Struct Mol Biol (2021) 28 pp. 258-267 [ Pubmed: 33633398 DOI: doi:10.1038/s41594-020-00554-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Nts-ntsr1-gi complex in lipid nanodisc (10 kDa, Complex)
- G(i) subunit alpha-1 (Complex from Homo sapiens)
- Ntsr1 (Complex from Rattus norvegicus)
- Neurotensin receptor type 1 (37 kDa, Protein from Rattus norvegicus)
- G(t) subunit gamma-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nts (Complex from Rattus norvegicus)
- Neurotensin (1 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(t) subunit gamma-t1 (9 kDa, Protein from Homo sapiens)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
Structure of NTS-NTSR1-Gi complex in lipid nanodisc, canonical state, overall
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7l0q
Q-score: 0.325
Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G
Nat Struct Mol Biol (2021) 28 pp. 258-267 [ Pubmed: 33633398 DOI: doi:10.1038/s41594-020-00554-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Nts-ntsr1-gi complex in lipid nanodisc (10 kDa, Complex)
- G(i) subunit alpha-1 (Complex from Homo sapiens)
- Ntsr1 (Complex from Rattus norvegicus)
- Neurotensin receptor type 1 (37 kDa, Protein from Rattus norvegicus)
- G(t) subunit gamma-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nts (Complex from Rattus norvegicus)
- Neurotensin (1 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(t) subunit gamma-t1 (9 kDa, Protein from Homo sapiens)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, AHD and nanodisc mask out
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7l0r
Q-score: 0.311
Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G
Nat Struct Mol Biol (2021) 28 pp. 258-267 [ Pubmed: 33633398 DOI: doi:10.1038/s41594-020-00554-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Nts-ntsr1-gi complex in lipid nanodisc (10 kDa, Complex)
- G(i) subunit alpha-1 (Complex from Homo sapiens)
- Ntsr1 (Complex from Rattus norvegicus)
- Neurotensin receptor type 1 (37 kDa, Protein from Rattus norvegicus)
- G(t) subunit gamma-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nts (Complex from Rattus norvegicus)
- Neurotensin (1 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(t) subunit gamma-t1 (9 kDa, Protein from Homo sapiens)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
Structure of NTS-NTSR1-Gi complex in lipid nanodisc, noncanonical state, overall
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7l0s
Q-score: 0.278
Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G
Nat Struct Mol Biol (2021) 28 pp. 258-267 [ Pubmed: 33633398 DOI: doi:10.1038/s41594-020-00554-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Nts-ntsr1-gi complex in lipid nanodisc (10 kDa, Complex)
- G(i) subunit alpha-1 (Complex from Homo sapiens)
- Ntsr1 (Complex from Rattus norvegicus)
- Neurotensin receptor type 1 (37 kDa, Protein from Rattus norvegicus)
- G(t) subunit gamma-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nts (Complex from Rattus norvegicus)
- Neurotensin (1 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(t) subunit gamma-t1 (9 kDa, Protein from Homo sapiens)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)