Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7pdf
Q-score: 0.445
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Adenylyl cyclase 9 (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (47 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- 5'-guanosine-diphosphate-monothiophosphate (539 Da, Ligand)
Structure of Adenylyl cyclase 9 in complex with Gs protein alpha subunit and MANT-GTP
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7pde
Q-score: 0.288
Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM
Nat Commun (2022) 13 pp. 1045-1045 [ DOI: doi:10.1038/s41467-022-28685-y Pubmed: 35210418 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (47 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Adenylyl cyclase 9 bound to mant-gtp (146 MDa, Complex)
- Adenylate cyclase 9 (151 kDa, Protein from Bos taurus)
- Adenylate cyclase 9 (Complex from Bos taurus)
- 5'-guanosine-diphosphate-monothiophosphate (539 Da, Ligand)
Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 7p00
Q-score: 0.546
Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A
Sci Adv (2021) 7 pp. eabk2872-eabk2872 [ DOI: doi:10.1126/sciadv.abk2872 Pubmed: 34878828 ]
- Substance p (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (32 kDa, Protein from Mus musculus)
- Substance-p receptor (44 kDa, Protein from Homo sapiens)
- Nk1r in complex with substance p, heterotrimeric mini-gq chimera (gsqi) and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Human Neurokinin 1 receptor (NK1R) substance P Gs complex
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7p02
Q-score: 0.502
Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A
Sci Adv (2021) 7 pp. eabk2872-eabk2872 [ DOI: doi:10.1126/sciadv.abk2872 Pubmed: 34878828 ]
- Antibody fragment scfv16 (32 kDa, Protein from Mus musculus)
- Substance-p receptor (44 kDa, Protein from Homo sapiens)
- Protachykinin-1 (1 kDa, Protein from Homo sapiens)
- Nk1r in complex with substance p, heterotrimeric mini-gs chimera (gsi) and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)