CryoEM structure of SARS-CoV-2 spike monomer in complex with neutralising antibody P008_60
Resolution: 4.31 Å
EM Method: Single-particle
Fitted PDBs: 7zbu
Q-score: 0.209
Seow J, Khan H, Rosa A, Calvaresi V, Graham C, Pickering S, Pye VE, Cronin NB, Huettner I, Malim MH, Politis A, Cherepanov P, Doores KJ
Cell Rep (2022) 40 pp. 111276-111276 [ Pubmed: 35981534 DOI: doi:10.1016/j.celrep.2022.111276 ]
- Monomeric spike glycoprotein ectodomain from sars-cov-2 in complex with a neutralising antibody p008_60 (125 kDa, Complex from Homo sapiens)
- P008_60 antibody, heavy chain (25 kDa, Protein from Homo sapiens)
- 3-[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-2-[[5-[(3-ethyl-4-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1h-pyrrol-2-yl]methyl]-4-methyl-1h-pyrrol-3-yl]propanoic acid (588 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- P008_60 antibody, light chain (23 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.4 Å
EM Method: Single-particle
Fitted PDBs: 6r6h
Q-score: 0.146
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Eloc_human (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (34 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Rbx1_human (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (17 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cullin-ring e3 ligases (crls) complexes with neddylated cop9 signalosome (csn) (Complex from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7f
Q-score: 0.001
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (18 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Ternary complex of cop9 signalosome (csn) and neddylated cullin-ring e3 ligase crl (cullin-2 with rbx1, elongin-b, elongin-c and vhl) (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.8 Å
EM Method: Single-particle
Fitted PDBs: 6r7h
Q-score: 0.05
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 2 (48 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- Ternary complex of cop9 signalosome (csn1-csn8) with cullin-ring e3 ligase deneddylated cullin-2, rbx1, elongin-b and elonginc (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
- Cullin-2 (76 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 6r7i
Q-score: 0.148
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Elongin-c (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Csn-crl2-n8 (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cop9 signalosome complex subunit 1 (52 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6r7n
Q-score: 0.136
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cns (cop9 signalosome) with csn5/csn6 the catalytic heterodimer complexed with cul2 (cul2, elonginb, elongingc, rbx1 and vdl) (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Rbx1 e3 ubiquitin-protein ligase (10 kDa, Protein from Homo sapiens)
- Csn7b_human (23 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
Electron microscopy of the CSM/RNA complex from Sulfolobus solfataricus
Rouillon C, Zhou M, Zhang J, Politis A, Beilsten V, Cannone G, Graham S, Robinson CV, Spagnolo L, White MF
Mol Cell (2013) 52 pp. 124-134 [ DOI: doi:10.1016/j.molcel.2013.08.020 Pubmed: 24119402 ]