a peptide receptor complex structure
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xgu
Q-score: 0.482
Wu Z, Chen G, Qiu C, Yan X, Xu L, Jiang S, Xu J, Han R, Shi T, Liu Y, Gao W, Wang Q, Li J, Ye F, Pan X, Zhang Z, Ning P, Zhang B, Chen J, Du Y
Sci Adv (2024) 10 pp. eadn7771-eadn7771 [ Pubmed: 39151001 DOI: doi:10.1126/sciadv.adn7771 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Kp54-kiss1r-gq-scfv16 (130 kDa, Complex from Homo sapiens)
- Kiss1r (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2,guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Kiss-1 receptor (42 kDa, Protein from Homo sapiens)
- Tak448 (1 kDa, Protein from synthetic construct)
INTS9-INTS11-BRAT1-WDR73 complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8r22
Q-score: 0.464
Mol Cell (2024) 84 pp. 2882-2899.e10 [ DOI: doi:10.1016/j.molcel.2024.06.032 Pubmed: 39032489 ]
- Integrator complex subunit 11 (68 kDa, Protein from Homo sapiens)
- Brca1-associated atm activator 1 (88 kDa, Protein from Homo sapiens)
- Protein complex (Complex from Homo sapiens)
- Wd repeat-containing protein 73 (42 kDa, Protein from Homo sapiens)
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8r23
Q-score: 0.535
Mol Cell (2024) 84 pp. 2882-2899.e10 [ Pubmed: 39032489 DOI: doi:10.1016/j.molcel.2024.06.032 ]
- Brca1-associated atm activator 1 (88 kDa, Protein from Homo sapiens)
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ints9-ints11-brat1 complex (Complex from Homo sapiens)
- Integrator complex subunit 11 (68 kDa, Protein from Homo sapiens)
Integrator cleavage module assembly intermediate
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8r2d
Q-score: 0.389
Mol Cell (2024) 84 pp. 2882-2899.e10 [ DOI: doi:10.1016/j.molcel.2024.06.032 Pubmed: 39032489 ]
- Zinc ion (65 Da, Ligand)
- Integrator complex subunit 11 (68 kDa, Protein from Homo sapiens)
- Brca1-associated atm activator 1 (88 kDa, Protein from Homo sapiens)
- Ints4-ints9-ints11-brat1 complex (Complex from Homo sapiens)
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Integrator complex subunit 4 (109 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8ij3
Q-score: 0.506
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ Pubmed: 38012147 DOI: doi:10.1038/s41421-023-00610-7 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex without ligand (apo state) (Complex from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with acipimox
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8ijb
Q-score: 0.497
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
- Cryo-em structure of human hcar2-gi complex with acipimox (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with MK-6892
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8ijd
Q-score: 0.452
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with mk-6892 (Complex from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)