INTS9-INTS11-BRAT1-WDR73 complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8r22
Q-score: 0.464
Mol Cell (2024) 84 pp. 2882-2899.e10 [ Pubmed: 39032489 DOI: doi:10.1016/j.molcel.2024.06.032 ]
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Brca1-associated atm activator 1 (88 kDa, Protein from Homo sapiens)
- Protein complex (Complex from Homo sapiens)
- Integrator complex subunit 11 (68 kDa, Protein from Homo sapiens)
- Wd repeat-containing protein 73 (42 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8r23
Q-score: 0.535
Mol Cell (2024) 84 pp. 2882-2899.e10 [ Pubmed: 39032489 DOI: doi:10.1016/j.molcel.2024.06.032 ]
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ints9-ints11-brat1 complex (Complex from Homo sapiens)
- Brca1-associated atm activator 1 (88 kDa, Protein from Homo sapiens)
- Integrator complex subunit 11 (68 kDa, Protein from Homo sapiens)
Integrator cleavage module assembly intermediate
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8r2d
Q-score: 0.389
Mol Cell (2024) 84 pp. 2882-2899.e10 [ Pubmed: 39032489 DOI: doi:10.1016/j.molcel.2024.06.032 ]
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ints4-ints9-ints11-brat1 complex (Complex from Homo sapiens)
- Integrator complex subunit 4 (109 kDa, Protein from Homo sapiens)
- Brca1-associated atm activator 1 (88 kDa, Protein from Homo sapiens)
- Integrator complex subunit 11 (68 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with niacin
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8ija
Q-score: 0.574
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with niacin (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with MK-6892
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8ijd
Q-score: 0.452
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Cryo-em structure of human hcar2-gi complex with mk-6892 (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)