Degrader-induced complex between PTPN2 and CRBN-DDB1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8uh6
Q-score: 0.266
Hao Q, Rathinaswamy MK, Klinge KL, Bratkowski M, Mafi A, Baumgartner CK, Hamel KM, Veits GK, Jain R, Catalano C, Fitzgerald M, Hird AW, Park E, Vora HU, Henderson JA, Longenecker K, Hutchins CW, Qiu W, Scapin G, Sun Q, Stoll VS, Sun C, Li P, Eaton D, Stokoe D, Fisher SL, Nasveschuk CG, Paddock M, Kort ME
Commun Chem (2024) 7 pp. 183-183 [ Pubmed: 39152201 DOI: doi:10.1038/s42004-024-01263-7 ]
- Tyrosine-protein phosphatase non-receptor type 2 (37 kDa, Protein from Homo sapiens)
- Crbn-ddb1-ptpn2 complex (217 kDa, Complex from Homo sapiens)
- Dna damage-binding protein 1 (128 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (5p)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4s)-1-({3-[(4-{1-[(3r)-2,6-dioxopiperidin-3-yl]-3-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl}piperidine-1-carbonyl)amino]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid (976 Da, Ligand)
- Protein cereblon (51 kDa, Protein from Homo sapiens)
Multidrug efflux pump subunit AcrB
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7rr6
Q-score: 0.52
Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y
Chem Sci (2023) 14 pp. 7310-7326 [ Pubmed: 37416719 DOI: doi:10.1039/d3sc01890c ]
- Multidrug efflux pump subunit acrb (Complex from Escherichia coli (strain K12))
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Phosphatidylethanolamine (734 Da, Ligand)
- Dodecane (170 Da, Ligand)
Multidrug efflux pump subunit AcrB
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7rr7
Q-score: 0.517
Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y
Chem Sci (2023) 14 pp. 7310-7326 [ Pubmed: 37416719 DOI: doi:10.1039/d3sc01890c ]
- Multidrug efflux pump subunit acrb (Complex from Escherichia coli (strain K12))
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Phosphatidylethanolamine (734 Da, Ligand)
Multidrug efflux pump subunit AcrB
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 7rr8
Q-score: 0.547
Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y
Chem Sci (2023) 14 pp. 7310-7326 [ Pubmed: 37416719 DOI: doi:10.1039/d3sc01890c ]
- Multidrug efflux pump subunit acrb (Complex from Escherichia coli (strain K12))
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Phosphatidylethanolamine (734 Da, Ligand)
Small conductance mechanosensitive channel MscS
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7raz
Q-score: 0.418
Catalano C, Ben-Hail D, Qiu W, des Georges A, Guo Y
To Be Published
Low conductance mechanosensitive channel YnaI
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7n4t
Q-score: 0.557
Catalano C, Ben-Hail D, Qiu W, Blount P, des Georges A, Guo Y
Membranes (Basel) (2021) 11 [ DOI: doi:10.3390/membranes11110849 Pubmed: 34832078 ]
Flagellar cap protein FiD on hook tip from FlaB deletion mutant of B. burgdorferi
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6baj
Q-score: 0.513
Qiu W, Fu Z, Xu GG, Grassucci RA, Zhang Y, Frank J, Hendrickson WA, Guo Y
PNAS (2018) 115 pp. 12985-12990 [ Pubmed: 30509977 DOI: doi:10.1073/pnas.1812526115 ]
- Water (18 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Native cell membrane nanoparticles of acrb (Complex from Escherichia coli)
- Phosphatidylethanolamine (734 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6csx
Q-score: 0.553
Qiu W, Fu Z, Xu GG, Grassucci RA, Zhang Y, Frank J, Hendrickson WA, Guo Y
PNAS (2018) 115 pp. 12985-12990 [ Pubmed: 30509977 DOI: doi:10.1073/pnas.1812526115 ]
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Lipid bilayer in acrb (Complex from Escherichia coli)
- Phosphatidylethanolamine (734 Da, Ligand)