Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8zqo
Q-score: 0.615
Structure (2024) [ DOI: doi:10.1016/j.str.2024.11.009 Pubmed: 39657660 ]
- Chloride ion (35 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Human high-affinity choline transporter cht1 bound to hc-3 under nacl condition, with sodium and chloride ions coordinated. (Complex from Homo sapiens)
- (2s,2's)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium) (414 Da, Ligand)
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8zqp
Q-score: 0.559
Structure (2024) [ DOI: doi:10.1016/j.str.2024.11.009 Pubmed: 39657660 ]
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- 4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-n-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide (387 Da, Ligand)
- Human high-affinity choline transporter cht1 bound to ml352 under nacl condition, with sodium ion coordinated. (Complex from Homo sapiens)
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8zqq
Q-score: 0.648
Structure (2024) [ DOI: doi:10.1016/j.str.2024.11.009 Pubmed: 39657660 ]
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Human high-affinity choline transporter cht1 bound to choline under nacl condition, with sodium and chloride ions coordinated. (Complex from Homo sapiens)
- Choline ion (104 Da, Ligand)
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
Human high-affinity choline transporter CHT1 in apo state under NaCl condition.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8zqr
Q-score: 0.469
Structure (2024) [ DOI: doi:10.1016/j.str.2024.11.009 Pubmed: 39657660 ]
The structure of Candida albicans Cdr1 in fluconazole-bound state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9iul
Q-score: 0.567
Peng Y, Lu Y, Sun H, Ma J, Li X, Han X, Fang Z, Tan J, Qiu Y, Qu T, Yin M, Yan Z
Nat Commun (2024) 15 pp. 7722-7722 [ Pubmed: 39242571 DOI: doi:10.1038/s41467-024-52107-w ]
- 2-(2,4-difluorophenyl)-1,3-di(1h-1,2,4-triazol-1-yl)propan-2-ol (306 Da, Ligand)
- Pip2(20:4/18:0) (1 kDa, Ligand)
- Pleiotropic abc efflux transporter of multiple drugs cdr1 (170 kDa, Protein from Candida albicans SC5314)
- The cryo-em structure of candida albicans cdr1 in fluconazole-bound state (Complex from Candida albicans SC5314)
The structure of Candida albicans Cdr1 in milbemycin oxime-inhibited state
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 9ium
Q-score: 0.547
Peng Y, Lu Y, Sun H, Ma J, Li X, Han X, Fang Z, Tan J, Qiu Y, Qu T, Yin M, Yan Z
Nat Commun (2024) 15 pp. 7722-7722 [ Pubmed: 39242571 DOI: doi:10.1038/s41467-024-52107-w ]
- Milbemycin oxime (555 Da, Ligand)
- The cryo-em structure of candida albicans cdr1 in milbemycin oxime-inhibited state (Complex from Candida albicans SC5314)
- Pip2(20:4/18:0) (1 kDa, Ligand)
- Pleiotropic abc efflux transporter of multiple drugs cdr1 (170 kDa, Protein from Candida albicans SC5314)
Cryo-EM structure of human dopamine transporter in complex with dopamine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ DOI: doi:10.1038/s41586-024-07796-0 Pubmed: 39112701 ]
- Chloride ion (35 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Human dopamine transporter in complex with dopamine (Complex from Homo sapiens)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
Cryo-EM structure of human dopamine transporter in complex with benztropine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ DOI: doi:10.1038/s41586-024-07796-0 Pubmed: 39112701 ]
- Human dopamine transporter in complex with benztropine (Complex from Homo sapiens)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Benztropine (307 Da, Ligand)