Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8j75
Q-score: 0.398
Human high-affinity choline transporter CHT1 in the inward-facing apo-open conformation
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8j76
Q-score: 0.395
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8j77
Q-score: 0.42
Qiu Y, Gao Y, Huang B, Bai Q, Zhao Y
Nat Struct Mol Biol (2024) 31 pp. 701-709 [ DOI: doi:10.1038/s41594-024-01259-w Pubmed: 38589607 ]
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
- Human high-affinity choline transporter 1 (Complex from Homo sapiens)
- Choline ion (104 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8j74
Q-score: 0.44
Qiu Y, Gao Y, Huang B, Bai Q, Zhao Y
Nat Struct Mol Biol (2024) 31 pp. 701-709 [ Pubmed: 38589607 DOI: doi:10.1038/s41594-024-01259-w ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human high-affinity choline transporter 1 (Complex from Homo sapiens)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Hexadecane (226 Da, Ligand)
- (2s,2's)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium) (414 Da, Ligand)
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
Cryo-EM structure of human NaV1.6/beta1/beta2,apo state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8gz1
Q-score: 0.391
Li Y, Yuan T, Huang B, Zhou F, Peng C, Li X, Qiu Y, Yang B, Zhao Y, Huang Z, Jiang D
Nat Commun (2023) 14 pp. 1030-1030 [ DOI: doi:10.1038/s41467-023-36766-9 Pubmed: 36823201 ]
- Sodium ion (22 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Structure of human voltage-gated sodium channel nav1.6 in complex with auxiliary beta subunits (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 8 subunit alpha (225 kDa, Protein from Homo sapiens)
Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gz2
Q-score: 0.422
Li Y, Yuan T, Huang B, Zhou F, Peng C, Li X, Qiu Y, Yang B, Zhao Y, Huang Z, Jiang D
Nat Commun (2023) 14 pp. 1030-1030 [ DOI: doi:10.1038/s41467-023-36766-9 Pubmed: 36823201 ]
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Structure of human voltage-gated sodium channel nav1.6 in complex with auxiliary beta subunits (Complex from Homo sapiens)
- Sodium channel protein type 8 subunit alpha (225 kDa, Protein from Homo sapiens)
- (1r,2s,3s,4r,5r,9s,11s,12s,14r)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name) (301 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)