Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8zqo
Q-score: 0.615
Structure (2024) [ DOI: doi:10.1016/j.str.2024.11.009 Pubmed: 39657660 ]
- Human high-affinity choline transporter cht1 bound to hc-3 under nacl condition, with sodium and chloride ions coordinated. (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- (2s,2's)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium) (414 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8zqp
Q-score: 0.559
Structure (2024) [ DOI: doi:10.1016/j.str.2024.11.009 Pubmed: 39657660 ]
- 4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-n-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide (387 Da, Ligand)
- Human high-affinity choline transporter cht1 bound to ml352 under nacl condition, with sodium ion coordinated. (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8zqq
Q-score: 0.648
Structure (2024) [ DOI: doi:10.1016/j.str.2024.11.009 Pubmed: 39657660 ]
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Human high-affinity choline transporter cht1 bound to choline under nacl condition, with sodium and chloride ions coordinated. (Complex from Homo sapiens)
- Choline ion (104 Da, Ligand)
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
The structure of Candida albicans Cdr1 in fluconazole-bound state
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9iul
Q-score: 0.567
Peng Y, Lu Y, Sun H, Ma J, Li X, Han X, Fang Z, Tan J, Qiu Y, Qu T, Yin M, Yan Z
Nat Commun (2024) 15 pp. 7722-7722 [ Pubmed: 39242571 DOI: doi:10.1038/s41467-024-52107-w ]
- 2-(2,4-difluorophenyl)-1,3-di(1h-1,2,4-triazol-1-yl)propan-2-ol (306 Da, Ligand)
- Pip2(20:4/18:0) (1 kDa, Ligand)
- Pleiotropic abc efflux transporter of multiple drugs cdr1 (170 kDa, Protein from Candida albicans SC5314)
- The cryo-em structure of candida albicans cdr1 in fluconazole-bound state (Complex from Candida albicans SC5314)
Cryo-EM structure of human dopamine transporter in complex with dopamine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ DOI: doi:10.1038/s41586-024-07796-0 Pubmed: 39112701 ]
- Chloride ion (35 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Human dopamine transporter in complex with dopamine (Complex from Homo sapiens)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
Cryo-EM structure of human dopamine transporter in complex with benztropine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ DOI: doi:10.1038/s41586-024-07796-0 Pubmed: 39112701 ]
- Human dopamine transporter in complex with benztropine (Complex from Homo sapiens)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Benztropine (307 Da, Ligand)
structure of a proteinACryo-EM structure of human dopamine transporter in complex with GBR12909
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ DOI: doi:10.1038/s41586-024-07796-0 Pubmed: 39112701 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- Vanoxerine (450 Da, Ligand)
- Human dopamine transporter in complex with gbr12909 (Complex from Homo sapiens)
Cryo-EM structure of human dopamine transporter in complex with methylphenidate
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ DOI: doi:10.1038/s41586-024-07796-0 Pubmed: 39112701 ]
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent dopamine transporter (62 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human dopamine transporter in complex with methylphenidate (Complex from Homo sapiens)
- Dexmethylphenidate (233 Da, Ligand)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8j77
Q-score: 0.42
Qiu Y, Gao Y, Huang B, Bai Q, Zhao Y
Nat Struct Mol Biol (2024) 31 pp. 701-709 [ DOI: doi:10.1038/s41594-024-01259-w Pubmed: 38589607 ]
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
- Human high-affinity choline transporter 1 (Complex from Homo sapiens)
- Choline ion (104 Da, Ligand)