Cryo-EM structure of human dopamine transporter in complex with dopamine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- Water (18 Da, Ligand)
- Human dopamine transporter in complex with dopamine (Complex from Homo sapiens)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- L-dopamine (153 Da, Ligand)
Cryo-EM structure of human dopamine transporter in complex with benztropine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human dopamine transporter in complex with benztropine (Complex from Homo sapiens)
- Benztropine (307 Da, Ligand)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
structure of a proteinACryo-EM structure of human dopamine transporter in complex with GBR12909
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human dopamine transporter in complex with gbr12909 (Complex from Homo sapiens)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- Vanoxerine (450 Da, Ligand)
Cryo-EM structure of human dopamine transporter in complex with methylphenidate
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- Chloride ion (35 Da, Ligand)
- Sodium-dependent dopamine transporter (62 kDa, Protein from Homo sapiens)
- Human dopamine transporter in complex with methylphenidate (Complex from Homo sapiens)
- Dexmethylphenidate (233 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human NaV1.6/beta1/beta2,apo state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8gz1
Q-score: 0.391
Li Y, Yuan T, Huang B, Zhou F, Peng C, Li X, Qiu Y, Yang B, Zhao Y, Huang Z, Jiang D
Nat Commun (2023) 14 pp. 1030-1030 [ Pubmed: 36823201 DOI: doi:10.1038/s41467-023-36766-9 ]
- Sodium channel protein type 8 subunit alpha (225 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Structure of human voltage-gated sodium channel nav1.6 in complex with auxiliary beta subunits (Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gz2
Q-score: 0.422
Li Y, Yuan T, Huang B, Zhou F, Peng C, Li X, Qiu Y, Yang B, Zhao Y, Huang Z, Jiang D
Nat Commun (2023) 14 pp. 1030-1030 [ Pubmed: 36823201 DOI: doi:10.1038/s41467-023-36766-9 ]
- Sodium channel protein type 8 subunit alpha (225 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Structure of human voltage-gated sodium channel nav1.6 in complex with auxiliary beta subunits (Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- (1r,2s,3s,4r,5r,9s,11s,12s,14r)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name) (301 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xlq
Q-score: 0.482
Gao Y, Xu S, Cui X, Xu H, Qiu Y, Wei Y, Dong Y, Zhu B, Peng C, Liu S, Zhang XC, Sun J, Huang Z, Zhao Y
Nat Commun (2023) 14 pp. 516-516 [ DOI: doi:10.1038/s41467-023-36260-2 Pubmed: 36720859 ]
- Hexadecane (226 Da, Ligand)
- Human r-type voltage-gated calcium channel cav2.3-alpha2/delta1-beta1 complex (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (65 kDa, Protein from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (122 kDa, Protein from Homo sapiens)
- Voltage-dependent r-type calcium channel subunit alpha-1e (262 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)