Cryo-EM structure of human dopamine transporter in complex with dopamine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- Human dopamine transporter in complex with dopamine (Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of human dopamine transporter in complex with benztropine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Benztropine (307 Da, Ligand)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- Human dopamine transporter in complex with benztropine (Complex from Homo sapiens)
structure of a proteinACryo-EM structure of human dopamine transporter in complex with GBR12909
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- Vanoxerine (450 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- Human dopamine transporter in complex with gbr12909 (Complex from Homo sapiens)
Cryo-EM structure of human dopamine transporter in complex with methylphenidate
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dexmethylphenidate (233 Da, Ligand)
- Human dopamine transporter in complex with methylphenidate (Complex from Homo sapiens)
- Sodium-dependent dopamine transporter (62 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8j77
Q-score: 0.42
Qiu Y, Gao Y, Huang B, Bai Q, Zhao Y
Nat Struct Mol Biol (2024) 31 pp. 701-709 [ DOI: doi:10.1038/s41594-024-01259-w Pubmed: 38589607 ]
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
- Choline ion (104 Da, Ligand)
- Human high-affinity choline transporter 1 (Complex from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8j74
Q-score: 0.44
Qiu Y, Gao Y, Huang B, Bai Q, Zhao Y
Nat Struct Mol Biol (2024) 31 pp. 701-709 [ DOI: doi:10.1038/s41594-024-01259-w Pubmed: 38589607 ]
- (2s,2's)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium) (414 Da, Ligand)
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human high-affinity choline transporter 1 (Complex from Homo sapiens)
Cryo-EM structure of human NaV1.6/beta1/beta2,apo state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8gz1
Q-score: 0.391
Li Y, Yuan T, Huang B, Zhou F, Peng C, Li X, Qiu Y, Yang B, Zhao Y, Huang Z, Jiang D
Nat Commun (2023) 14 pp. 1030-1030 [ Pubmed: 36823201 DOI: doi:10.1038/s41467-023-36766-9 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 8 subunit alpha (225 kDa, Protein from Homo sapiens)
- Structure of human voltage-gated sodium channel nav1.6 in complex with auxiliary beta subunits (Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of human NaV1.6/beta1/beta2-4,9-anhydro-tetrodotoxin
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gz2
Q-score: 0.422
Li Y, Yuan T, Huang B, Zhou F, Peng C, Li X, Qiu Y, Yang B, Zhao Y, Huang Z, Jiang D
Nat Commun (2023) 14 pp. 1030-1030 [ Pubmed: 36823201 DOI: doi:10.1038/s41467-023-36766-9 ]
- (1r,2s,3s,4r,5r,9s,11s,12s,14r)-7-amino-2,4,12-trihydroxy-2-(hydroxymethyl)-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1~3,12~.0~5,11~.0~5,14~]pentadec-7-en-8-ium (non-preferred name) (301 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 8 subunit alpha (225 kDa, Protein from Homo sapiens)
- Structure of human voltage-gated sodium channel nav1.6 in complex with auxiliary beta subunits (Complex from Homo sapiens)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xlq
Q-score: 0.482
Gao Y, Xu S, Cui X, Xu H, Qiu Y, Wei Y, Dong Y, Zhu B, Peng C, Liu S, Zhang XC, Sun J, Huang Z, Zhao Y
Nat Commun (2023) 14 pp. 516-516 [ DOI: doi:10.1038/s41467-023-36260-2 Pubmed: 36720859 ]
- Voltage-dependent r-type calcium channel subunit alpha-1e (262 kDa, Protein from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-1 (65 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (122 kDa, Protein from Homo sapiens)
- Hexadecane (226 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Human r-type voltage-gated calcium channel cav2.3-alpha2/delta1-beta1 complex (Complex from Homo sapiens)