Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8zqo
Q-score: 0.615
Structure (2025) 33 pp. 321- [ Pubmed: 39657660 DOI: doi:10.1016/j.str.2024.11.009 ]
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Human high-affinity choline transporter cht1 bound to hc-3 under nacl condition, with sodium and chloride ions coordinated. (Complex from Homo sapiens)
- (2s,2's)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium) (414 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8zqp
Q-score: 0.559
Structure (2025) 33 pp. 321- [ Pubmed: 39657660 DOI: doi:10.1016/j.str.2024.11.009 ]
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
- 4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-n-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide (387 Da, Ligand)
- Human high-affinity choline transporter cht1 bound to ml352 under nacl condition, with sodium ion coordinated. (Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Water (18 Da, Ligand)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8zqq
Q-score: 0.648
Structure (2025) 33 pp. 321- [ Pubmed: 39657660 DOI: doi:10.1016/j.str.2024.11.009 ]
- Choline ion (104 Da, Ligand)
- High affinity choline transporter 1 (63 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Human high-affinity choline transporter cht1 bound to choline under nacl condition, with sodium and chloride ions coordinated. (Complex from Homo sapiens)
Human high-affinity choline transporter CHT1 in apo state under NaCl condition.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8zqr
Q-score: 0.469
Structure (2025) 33 pp. 321- [ Pubmed: 39657660 DOI: doi:10.1016/j.str.2024.11.009 ]
Cryo-EM structure of human dopamine transporter in complex with dopamine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- Human dopamine transporter in complex with dopamine (Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of human dopamine transporter in complex with benztropine
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Benztropine (307 Da, Ligand)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- Human dopamine transporter in complex with benztropine (Complex from Homo sapiens)
structure of a proteinACryo-EM structure of human dopamine transporter in complex with GBR12909
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- Vanoxerine (450 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent dopamine transporter (61 kDa, Protein from Homo sapiens)
- Human dopamine transporter in complex with gbr12909 (Complex from Homo sapiens)
Cryo-EM structure of human dopamine transporter in complex with methylphenidate
Li Y, Wang X, Meng Y, Hu T, Zhao J, Li R, Bai Q, Yuan P, Han J, Hao K, Wei Y, Qiu Y, Li N, Zhao Y
Nature (2024) 632 pp. 686-694 [ Pubmed: 39112701 DOI: doi:10.1038/s41586-024-07796-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dexmethylphenidate (233 Da, Ligand)
- Human dopamine transporter in complex with methylphenidate (Complex from Homo sapiens)
- Sodium-dependent dopamine transporter (62 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8j75
Q-score: 0.398