SLC19A3-thiamine outward structure
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8z7s
Q-score: 0.541
SLC19A3-Pyridoxine outward structure
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8z7t
Q-score: 0.492
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol (169 Da, Ligand)
- Slc19a3 (Complex from Homo sapiens)
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
SLC19A3-Fedratinib outward structure
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8z7u
Q-score: 0.535
SLC19A3-Metformin outward structure
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8z7w
Q-score: 0.533
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- Metformin (129 Da, Ligand)
- Slc19a3 (Complex from Homo sapiens)
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
SLC19A3-Thiamine inward structure
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8z7x
Q-score: 0.443
SLC19A3-Fedratinib inward structure
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8z7y
Q-score: 0.484
SLC19A2-Thiamine inward structure
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8z7z
Q-score: 0.389
SLC19A2-Pyridoxine inward structure
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8z80
Q-score: 0.288
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- Slc19a3-thiamine complex (Complex from Homo sapiens)
- Thiamine transporter 1 (55 kDa, Protein from Homo sapiens)
- 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol (169 Da, Ligand)
Cryo-EM structure of the GPI inositol-deacylase (PGAP1/Bst1) from Chaetomium thermophilum
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8k9q
Q-score: 0.563
Hong J, Li T, Chao Y, Xu Y, Zhu Z, Zhou Z, Gu W, Qu Q, Li D
Nat Commun (2024) 15 pp. 8-8 [ DOI: doi:10.1038/s41467-023-44568-2 Pubmed: 38167496 ]
- Gpi inositol-deacylase (163 kDa, Complex from Thermochaetoides thermophila)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Gpi inositol-deacylase,fused thermostable green fluorescent protein (163 kDa, Protein from synthetic construct)
- (2~{s})-2-azanyl-3-[[(2~{r})-3-hexadecanoyloxy-2-[(~{z})-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid (762 Da, Ligand)
Cryo EM structure of the products-bound PGAP1(Bst1)-H443N from Chaetomium thermophilum
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8k9r
Q-score: 0.604
Hong J, Li T, Chao Y, Xu Y, Zhu Z, Zhou Z, Gu W, Qu Q, Li D
Nat Commun (2024) 15 pp. 8-8 [ DOI: doi:10.1038/s41467-023-44568-2 Pubmed: 38167496 ]
- Complex of the gpi inositol-deacylase with a chimera gpi-anchored protein (194 kDa, Complex from Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719))
- Palmitic acid (256 Da, Ligand)
- 2-amino-2-deoxy-alpha-d-glucopyranose (179 Da, Ligand)
- [(2~{r})-1-octadecoxy-3-[oxidanyl-[(2~{r},3~{r},5~{s},6~{r})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] octadecanoate (853 Da, Ligand)
- 2-azanylethyl [(2~{s},3~{s},4~{s},5~{s},6~{r})-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl] hydrogen phosphate (303 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Green fluorescent protein,complement decay-accelerating factor (29 kDa, Protein from Homo sapiens)
- Gpi inositol-deacylase,mcherry protein (161 kDa, Protein from Psychromonas sp. B3M02)
- 2-azanylethyl [(2r,3s,4s,5s,6s)-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hydrogen phosphate (303 Da, Ligand)
- Alpha-d-mannopyranose (180 Da, Ligand)