CryoEM structure of SGLT1 at 3.4 A resolution
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl8
Q-score: 0.467
Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L
Nature (2022) 601 pp. 274-279 [ Pubmed: 34880492 DOI: doi:10.1038/s41586-021-04211-w ]
- Nanobody nb1 (14 kDa, Protein from synthetic construct)
- Sodium/glucose cotransporter 1 (74 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nanobody-sglt complex (Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7sl9
Q-score: 0.463
Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L
Nature (2022) 601 pp. 274-279 [ Pubmed: 34880492 DOI: doi:10.1038/s41586-021-04211-w ]
- Butanoic acid (88 Da, Ligand)
- Sodium-coupled monocarboxylate transporter 1 (67 kDa, Protein from Homo sapiens)
- Smct1 and nanobody complex (Complex from Homo sapiens)
- Nanobody nb2 (14 kDa, Protein from synthetic construct)
CryoEM structure of SGLT1 at 3.15 angstrom resolution
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7sla
Q-score: 0.505
Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L
Nature (2022) 601 pp. 274-279 [ DOI: doi:10.1038/s41586-021-04211-w Pubmed: 34880492 ]
- Nanobody nb1 (14 kDa, Protein from synthetic construct)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium/glucose cotransporter 1 (74 kDa, Protein from Homo sapiens)
- Sglt1 and nanobody complex (Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7v6y
Q-score: 0.448
Luo Y, Wan G, Zhang X, Zhou X, Wang Q, Fan J, Cai H, Ma L, Wu H, Qu Q, Cong Y, Zhao Y, Li D
Structure (2021) 29 pp. 1286- [ Pubmed: 34174188 DOI: doi:10.1016/j.str.2021.06.004 ]
- (2s)-2-azanyl-3-[[(2s)-3-butanoyloxy-2-dec-9-enoyloxy-propoxy]-oxidanyl-phosphoryl]oxy-propanoic acid (481 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein patched homolog 1,protein patched homolog 1 (121 kDa, Protein from Mus musculus)
- Ptc1 in lipid nanodisc (160 MDa, Complex from Mus musculus)
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 7v6z
Q-score: 0.392
Luo Y, Wan G, Zhang X, Zhou X, Wang Q, Fan J, Cai H, Ma L, Wu H, Qu Q, Cong Y, Zhao Y, Li D
Structure (2021) 29 pp. 1286- [ Pubmed: 34174188 DOI: doi:10.1016/j.str.2021.06.004 ]
- Protein patched homolog 1,protein patched homolog 1 (121 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ptc1 in lipid nanodisc (160 MDa, Complex from Mus musculus)
Structure of the Epstein-Barr virus GPCR BILF1 in complex with human Gi
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7jhj
Q-score: 0.54
Tsutsumi N, Qu Q, Mavri M, Baggesen MS, Maeda S, Waghray D, Berg C, Kobilka BK, Rosenkilde MM, Skiniotis G, Garcia KC
Immunity (2021) 54 pp. 1405-1416.e7 [ Pubmed: 34216564 DOI: doi:10.1016/j.immuni.2021.06.001 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Bilf1 (40 kDa, Complex from Human gammaherpesvirus 4)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
- Scfv16 (30 kDa, Complex from Mus musculus)
- Bilf1 (35 kDa, Protein from Epstein-Barr virus)
- Bilf1-gi-scfv16 complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gi heterotrimer (70 kDa, Complex from Homo sapiens)