Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7rkf
Q-score: 0.44
Tsutsumi N, Maeda S, Qu Q, Voegele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC
Sci Adv (2022) 8 pp. eabl5442- [ DOI: doi:10.1126/sciadv.abl5442 ]
- Scfv16 (30 kDa, Complex from Mus musculus)
- G-protein coupled receptor homolog us28 (42 kDa, Protein from Human cytomegalovirus)
- Guanine nucleotide-binding protein subunit alpha-11 (41 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- G11in18 heterotrimer (90 kDa, Complex from Homo sapiens)
- Fractalkine (10 kDa, Protein from Homo sapiens)
- Cx3cl1-us28-g11in18-scfv16 complex (Complex)
- Cx3cl1-us28 (50 kDa, Complex from Human betaherpesvirus 5)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Structure of CX3CL1-US28-Gi-scFv16 in C-state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7rkm
Q-score: 0.477
Tsutsumi N, Maeda S, Qu Q, Voegele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC
Sci Adv (2022) 8 pp. eabl5442- [ DOI: doi:10.1126/sciadv.abl5442 ]
- Gi heterotrimer (90 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cx3cl1-us28-gi-scfv16 complex (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Fractalkine (10 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
- Cx3cl1-us28 (50 kDa, Complex from Human betaherpesvirus 5)
- Cholesterol (386 Da, Ligand)
- Scfv16 (30 kDa, Complex from Mus musculus)
- G-protein coupled receptor homolog us28 (42 kDa, Protein from Human betaherpesvirus 5)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Structure of CX3CL1-US28-Gi-scFv16 in OC-state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7rkn
Q-score: 0.447
Tsutsumi N, Maeda S, Qu Q, Voegele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC
Sci Adv (2022) 8 pp. eabl5442- [ DOI: doi:10.1126/sciadv.abl5442 ]
- Gi heterotrimer (90 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cx3cl1-us28-gi-scfv16 complex (Complex)
- G-protein coupled receptor homolog us28 (42 kDa, Protein from Human cytomegalovirus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Fractalkine (10 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
- Cx3cl1-us28 (50 kDa, Complex from Human betaherpesvirus 5)
- Scfv16 (30 kDa, Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Structure of the Epstein-Barr virus GPCR BILF1 in complex with human Gi
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7jhj
Q-score: 0.54
Tsutsumi N, Qu Q, Mavri M, Baggesen MS, Maeda S, Waghray D, Berg C, Kobilka BK, Rosenkilde MM, Skiniotis G, Garcia KC
Immunity (2021) 54 pp. 1405-1416.e7 [ Pubmed: 34216564 DOI: doi:10.1016/j.immuni.2021.06.001 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Bilf1 (40 kDa, Complex from Human gammaherpesvirus 4)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
- Scfv16 (30 kDa, Complex from Mus musculus)
- Bilf1 (35 kDa, Protein from Epstein-Barr virus)
- Bilf1-gi-scfv16 complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gi heterotrimer (70 kDa, Complex from Homo sapiens)
Structure of G-alpha-q bound to its chaperone Ric-8A
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6vu5
Q-score: 0.454
Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G
Cell Rep (2020) 30 pp. 3699-3709.e6 [ DOI: doi:10.1016/j.celrep.2020.02.086 Pubmed: 32126208 ]
Structure of G-alpha-i bound to its chaperone Ric-8A
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 6vu8
Q-score: 0.379
Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G
Cell Rep (2020) 30 pp. 3699-3709.e6 [ DOI: doi:10.1016/j.celrep.2020.02.086 Pubmed: 32126208 ]
Structure of histone H3k4 methyltransferase
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6bx3
Q-score: 0.297
Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G
Cell (2018) 174 pp. 1117-1126.e12 [ DOI: doi:10.1016/j.cell.2018.07.020 Pubmed: 30100186 ]
- Compass component swd3 (34 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Compass component sdc1 (4 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Multi-component complex of set1 with its core subunits cps25, cps30, cps40, cps50 and cps60 (220 kDa, Complex from Saccharomyces cerevisiae)
- Compass component bre2 (48 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Histone-lysine n-methyltransferase, h3 lysine-4 specific (32 kDa, Protein from Saccharomyces cerevisiae (strain YJM789))
- Compass component spp1 (28 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Compass component swd1 (47 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Mu Opioid Receptor-Gi Protein Complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6dde
Q-score: 0.407
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK
Nature (2018) 558 pp. 547-552 [ DOI: doi:10.1038/s41586-018-0219-7 Pubmed: 29899455 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Damgo (513 Da, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Ternary complex of damgo-activated mu-type opioid receptor with heterotrimeric gi, further stabilized by addition of scfv-16 (130 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Mu-type opioid receptor (39 kDa, Protein from Mus musculus)
Mu Opioid Receptor-Gi Protein Complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6ddf
Q-score: 0.416
Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK
Nature (2018) 558 pp. 547-552 [ DOI: doi:10.1038/s41586-018-0219-7 Pubmed: 29899455 ]
- Ternary complex of damgo-activated mu-type opioid receptor with heterotrimeric gi (120 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Damgo (513 Da, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mu-type opioid receptor (39 kDa, Protein from Mus musculus)
Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 5vai
Q-score: 0.297
Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G
Nature (2017) 546 pp. 248-253 [ DOI: doi:10.1038/nature22394 Pubmed: 28538729 ]
- The activated glucagon-like peptide-1 receptor in complex with the heterotrimeric gs protein (150 kDa, Complex from Oryctolagus cuniculus)
- Glucagon-like peptide 1 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Uncharacterized protein (52 kDa, Protein from Oryctolagus cuniculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Rattus norvegicus)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)