SLC19A3-thiamine outward structure
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8z7s
Q-score: 0.541
SLC19A3-Pyridoxine outward structure
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8z7t
Q-score: 0.492
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol (169 Da, Ligand)
- Slc19a3 (Complex from Homo sapiens)
SLC19A3-Fedratinib outward structure
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8z7u
Q-score: 0.535
SLC19A3-Metformin outward structure
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8z7w
Q-score: 0.533
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- Thiamine transporter 2 (55 kDa, Protein from Homo sapiens)
- Slc19a3 (Complex from Homo sapiens)
- Metformin (129 Da, Ligand)
SLC19A3-Thiamine inward structure
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 8z7x
Q-score: 0.443
SLC19A3-Fedratinib inward structure
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8z7y
Q-score: 0.484
SLC19A2-Thiamine inward structure
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8z7z
Q-score: 0.389
SLC19A2-Pyridoxine inward structure
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8z80
Q-score: 0.288
Li P, Zhu Z, Wang Y, Zhang X, Yang C, Zhu Y, Zhou Z, Chao Y, Long Y, Gao Y, Liu S, Zhang L, Gao P, Qu Q
Nat Commun (2024) 15 pp. 10924-10924 [ DOI: doi:10.1038/s41467-024-55359-8 Pubmed: 39738067 ]
- 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol (169 Da, Ligand)
- Thiamine transporter 1 (55 kDa, Protein from Homo sapiens)
- Slc19a3-thiamine complex (Complex from Homo sapiens)
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 8z8z
Q-score: 0.589
Xiong Q, Zhu Z, Li T, Li X, Zhou Z, Chao Y, Yang C, Feng S, Qu Q, Li D
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01474-5 Pubmed: 39824977 ]
- Lychos (127 kDa, Complex from Homo sapiens)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Water (18 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (4~{z},7~{z},10~{z},13~{z},16~{z},19~{z})-docosa-4,7,10,13,16,19-hexaenoate (764 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lysosomal cholesterol signaling protein,fluorescent protein (127 kDa, Protein from synthetic construct)
Bre1(mRBD-RING)/Rad6-Ub/nucleosome complex
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 8ieg
Q-score: 0.393
Deng Z, Ai H, Sun M, Tong Z, Du Y, Qu Q, Zhang L, Xu Z, Tao S, Shi Q, Li JB, Pan M, Liu L
Mol Cell (2023) 83 pp. 3080-3094.e14 [ DOI: doi:10.1016/j.molcel.2023.08.001 Pubmed: 37633270 ]
- Histone h2a type 1-b/e (11 kDa, Protein from Homo sapiens)
- Histone h3.1 (11 kDa, Protein from Homo sapiens)
- Histone h2b type 1-k (10 kDa, Protein from Homo sapiens)
- Histone h4 (9 kDa, Protein from Homo sapiens)
- Histone h2b type 1-k (10 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna (147-mer) (45 kDa, DNA from Homo sapiens)
- Bre1(mrbd-ring)/rad6-ub in complex with nucleosome (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna (147-mer) (45 kDa, DNA from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 2 (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- E3 ubiquitin-protein ligase bre1 (7 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))