Cryo-EM structure of the human FERRY complex
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7nd2
Q-score: 0.285
Quentin D, Schuhmacher JS, Klink BU, Lauer J, Shaikh TR, Huis In 't Veld PJ, Welp LM, Urlaub H, Zerial M, Raunser S
Mol Cell (2023) 83 pp. 1856-1871.e9 [ DOI: doi:10.1016/j.molcel.2023.05.009 Pubmed: 37267906 ]
- Protein phosphatase 1 regulatory subunit 21 (Complex from Homo sapiens)
- Quinone oxidoreductase-like protein 1 (Complex from Homo sapiens)
- Glutamine amidotransferase-like class 1 domain-containing protein 1 (Complex from Homo sapiens)
- Protein phosphatase 1 regulatory subunit 21 (88 kDa, Protein from Homo sapiens)
- Human ferry (five-subunit early endosome rna and ribosome intermediary) complex (Complex)
- Quinone oxidoreductase-like protein 1 (39 kDa, Protein from Homo sapiens)
- Glutamine amidotransferase-like class 1 domain-containing protein 1 (24 kDa, Protein from Homo sapiens)
Structure of the bacterial type VI secretion system effector RhsA.
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7q97
Q-score: 0.518
Gunther P, Quentin D, Ahmad S, Sachar K, Gatsogiannis C, Whitney JC, Raunser S
PLoS Pathog (2022) 18 pp. e1010182-e1010182 [ DOI: doi:10.1371/journal.ppat.1010182 Pubmed: 34986192 ]
- Structure of rhsa. (164 kDa, Cellular component from Pseudomonas protegens Pf-5)
- Rhs family protein (159 kDa, Protein from Pseudomonas protegens Pf-5)
Structure of VgrG1 from Pseudomonas protegens.
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7q5p
Q-score: 0.46
Gunther P, Quentin D, Ahmad S, Sachar K, Gatsogiannis C, Whitney JC, Raunser S
PLoS Pathog (2022) 18 pp. e1010182-e1010182 [ DOI: doi:10.1371/journal.ppat.1010182 Pubmed: 34986192 ]
TRPC4 in complex with inhibitor GFB-8749
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7b05
Q-score: 0.476
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-8749 (108 kDa, Complex from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
- 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{h}-pyridazin-6-one (360 Da, Ligand)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7b0j
Q-score: 0.581
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60603 Pubmed: 33236980 ]
- Trpc4 membrane protein (108 kDa, Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
TRPC4 in complex with inhibitor GFB-8438
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b0s
Q-score: 0.501
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Trpc4 in complex with inhibitor gfb-8438 (108 kDa, Cellular component from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- 5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{h}-pyridazin-6-one (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
TRPC4 in complex with inhibitor GFB-9289
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7b16
Q-score: 0.563
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- 5-chloranyl-4-(4-cyclohexyl-3-oxidanylidene-piperazin-1-yl)-1~{h}-pyridazin-6-one (310 Da, Ligand)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-9289 (108 kDa, Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
TRPC4 in complex with Calmodulin
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b1g
Q-score: 0.489
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Trpc4 membrane protein in complex with calmodulin (126 kDa, Cellular component)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Transient receptor potential cation channel subfamily c member 4a (Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (Cellular component from Mus musculus)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6zxj
Q-score: 0.396
Antoni C, Quentin D, Lang AE, Aktories K, Gatsogiannis C, Raunser S
PLoS Pathog (2020) 16 pp. e1008530-e1008530 [ DOI: doi:10.1371/journal.ppat.1008530 Pubmed: 32810181 ]
- Lethal factor (Complex from Bacillus anthracis)
- Fully-loaded anthrax lethal toxin in its heptameric pre-pore state (93 kDa, Complex)
- Lethal factor (93 kDa, Protein from Bacillus anthracis)
- Protective antigen (85 kDa, Protein from Bacillus anthracis)
- Protective antigen (Complex from Bacillus anthracis)
Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1B) arrangement
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6zxk
Q-score: 0.34
Antoni C, Quentin D, Lang AE, Aktories K, Gatsogiannis C, Raunser S
PLoS Pathog (2020) 16 pp. e1008530-e1008530 [ DOI: doi:10.1371/journal.ppat.1008530 Pubmed: 32810181 ]
- Lethal factor (93 kDa, Protein from Bacillus anthracis)
- Protective antigen (85 kDa, Protein from Bacillus anthracis)
- Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and pa7lf(2+1b) arrangement (720 kDa, Complex from Bacillus anthracis)