Cryo-EM structure of human type I OSM receptor complex: model for full extracellular assembly
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 8v29
Q-score: 0.219
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human osm in complex with gp130 and lifr (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Oncostatin-m (22 kDa, Protein from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
Cryo-EM structure of human type I OSM receptor complex: model for assembly core region
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8v2a
Q-score: 0.438
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Interleukin-6 receptor subunit beta (71 kDa, Protein from Homo sapiens)
- Human osm in complex with gp130 and lifr (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Oncostatin-m (22 kDa, Protein from Homo sapiens)
- Human osm (Complex from Homo sapiens)
- Leukemia inhibitory factor receptor (92 kDa, Protein from Homo sapiens)
- Gp130 and lifr (Complex from Homo sapiens)
Cryo-EM structure of mouse type II OSM receptor complex: model for full extracellular assembly
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8v2b
Q-score: 0.31
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Oncostatin-m-specific receptor subunit beta (82 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mouse osm in complex with gp130 and osmr (Complex)
- Interleukin-6 receptor subunit beta (70 kDa, Protein from Mus musculus)
- Oncostatin-m (20 kDa, Protein from Mus musculus)
Cryo-EM structure of mouse type II OSM receptor complex: model for assembly core region
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8v2c
Q-score: 0.479
Zhou Y, Stevis PE, Cao J, Ehrlich G, Jones J, Rafique A, Sleeman MW, Olson WC, Franklin MC
Nat Commun (2024) 15 pp. 9776-9776 [ DOI: doi:10.1038/s41467-024-54124-1 Pubmed: 39532904 ]
- Oncostatin-m-specific receptor subunit beta (82 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mouse osm in complex with gp130 and osmr (Complex)
- Interleukin-6 receptor subunit beta (70 kDa, Protein from Mus musculus)
- Oncostatin-m (20 kDa, Protein from Mus musculus)
Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8tg9
Q-score: 0.495
Dunn ME, Kithcart A, Kim JH, Ho AJ, Franklin MC, Romero Hernandez A, de Hoon J, Botermans W, Meyer J, Jin X, Zhang D, Torello J, Jasewicz D, Kamat V, Garnova E, Liu N, Rosconi M, Pan H, Karnik S, Burczynski ME, Zheng W, Rafique A, Nielsen JB, De T, Verweij N, Pandit A, Locke A, Chalasani N, Melander O, Schwantes-An TH, Baras A, Lotta LA, Musser BJ, Mastaitis J, Devalaraja-Narashimha KB, Rankin AJ, Huang T, Herman G, Olson W, Murphy AJ, Yancopoulos GD, Olenchock BA, Morton L
Nature (2024) 633 pp. 654-661 [ Pubmed: 39261724 DOI: doi:10.1038/s41586-024-07903-1 ]
- Regn5381 fab heavy chain (24 kDa, Protein from Mus musculus)
- Regn5381 fab light chain (23 kDa, Protein from Mus musculus)
- Active complex of npr1 ectodomain, anp, and regn5381 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atrial natriuretic peptide (3 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (52 kDa, Protein from Homo sapiens)
Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 8tga
Q-score: 0.117
Dunn ME, Kithcart A, Kim JH, Ho AJ, Franklin MC, Romero Hernandez A, de Hoon J, Botermans W, Meyer J, Jin X, Zhang D, Torello J, Jasewicz D, Kamat V, Garnova E, Liu N, Rosconi M, Pan H, Karnik S, Burczynski ME, Zheng W, Rafique A, Nielsen JB, De T, Verweij N, Pandit A, Locke A, Chalasani N, Melander O, Schwantes-An TH, Baras A, Lotta LA, Musser BJ, Mastaitis J, Devalaraja-Narashimha KB, Rankin AJ, Huang T, Herman G, Olson W, Murphy AJ, Yancopoulos GD, Olenchock BA, Morton L
Nature (2024) 633 pp. 654-661 [ Pubmed: 39261724 DOI: doi:10.1038/s41586-024-07903-1 ]
- Atrial natriuretic peptide receptor 1 (52 kDa, Protein from Homo sapiens)
- Regn5381 fab heavy chain (24 kDa, Protein from Mus musculus)
- Active-like complex of npr1 ectodomain and regn5381 fab, with no anp present (Complex from Homo sapiens)
- Regn5381 fab light chain (23 kDa, Protein from Mus musculus)
CryoEM structure of PN45545 TCR-CD3 complex
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 8es7
Q-score: 0.531
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45545 tcr beta chain (35 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Pn45545 tcr-cd3 complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pn45545 tcr alpha chain (30 kDa, Protein from Homo sapiens)
CryoEM structure of PN45545 TCR-CD3 in complex with HLA-A2 MAGEA4 (230-239)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8es8
Q-score: 0.537
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- Pn45545 tcr-cd3 complex bound to hla-a2 magea4 (230-239) with anti-beta-2-microglobulin fab (Complex from Homo sapiens)
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 (1 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45545 tcr beta chain (35 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
- Pn45545 tcr alpha chain (30 kDa, Protein from Homo sapiens)
CryoEM structure of PN45428 TCR-CD3 in complex with HLA-A2 MAGEA4
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8es9
Q-score: 0.475
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]
- T-cell surface glycoprotein cd3 zeta chain (19 kDa, Protein from Homo sapiens)
- Pn45428 tcr beta chain (35 kDa, Protein from Homo sapiens)
- Melanoma-associated antigen 4 (1 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Pn45428 tcr-cd3 complex bound to hla-a2 magea4 (230-239) in the presence of 2m2 fab (Complex from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (19 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pn45428 tcr alpha chain (30 kDa, Protein from Homo sapiens)
- Mhc class i antigen (32 kDa, Protein from Homo sapiens)
CryoEM structure of HLA-A2 bound to MAGEA4 (230-239) peptide
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8esa
Q-score: 0.527
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun (2023) 14 pp. 2401-2401 [ Pubmed: 37100770 DOI: doi:10.1038/s41467-023-37532-7 ]