Photorhabdus luminescens TcdA1 prepore-to-pore intermediate, K1179W mutant
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8cpz
Q-score: 0.526
Ng'ang'a PN, Folz J, Kucher S, Roderer D, Xu Y, Sitsel O, Belyy A, Prumbaum D, Kuhnemuth R, Assafa TE, Dong M, Seidel CAM, Bordignon E, Raunser S
Sci Adv (2025) 11 pp. eadr2019-eadr2019 [ Pubmed: 39752508 DOI: doi:10.1126/sciadv.adr2019 ]
- Tcda1 (1 MDa, Complex from Photorhabdus luminescens)
- Tcda1 (285 kDa, Protein from Photorhabdus luminescens)
Photorhabdus luminescens TcdA1 prepore-to-pore intermediate, K567W K2008W mutant
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8cq0
Q-score: 0.466
Ng'ang'a PN, Folz J, Kucher S, Roderer D, Xu Y, Sitsel O, Belyy A, Prumbaum D, Kuhnemuth R, Assafa TE, Dong M, Seidel CAM, Bordignon E, Raunser S
Sci Adv (2025) 11 pp. eadr2019-eadr2019 [ Pubmed: 39752508 DOI: doi:10.1126/sciadv.adr2019 ]
- Tcda1 (1 MDa, Complex from Photorhabdus luminescens)
- Tcda1 (285 kDa, Protein from Photorhabdus luminescens)
Photorhabdus luminescens TcdA1 prepore-to-pore intermediate, C16S, C20S, C870S, T1279C mutant
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8cq2
Q-score: 0.448
Ng'ang'a PN, Folz J, Kucher S, Roderer D, Xu Y, Sitsel O, Belyy A, Prumbaum D, Kuhnemuth R, Assafa TE, Dong M, Seidel CAM, Bordignon E, Raunser S
Sci Adv (2025) 11 pp. eadr2019-eadr2019 [ Pubmed: 39752508 DOI: doi:10.1126/sciadv.adr2019 ]
- Tcda1 (1 MDa, Complex from Photorhabdus luminescens)
- Tcda1 (285 kDa, Protein from Photorhabdus luminescens)
TRPC4 in complex with inhibitor GFB-8749
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7b05
Q-score: 0.476
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-8749 (108 kDa, Complex from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
- 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{h}-pyridazin-6-one (360 Da, Ligand)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7b0j
Q-score: 0.581
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60603 Pubmed: 33236980 ]
- Trpc4 membrane protein (108 kDa, Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
TRPC4 in complex with inhibitor GFB-8438
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b0s
Q-score: 0.501
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Trpc4 in complex with inhibitor gfb-8438 (108 kDa, Cellular component from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- 5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{h}-pyridazin-6-one (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
TRPC4 in complex with inhibitor GFB-9289
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7b16
Q-score: 0.563
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- 5-chloranyl-4-(4-cyclohexyl-3-oxidanylidene-piperazin-1-yl)-1~{h}-pyridazin-6-one (310 Da, Ligand)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-9289 (108 kDa, Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
TRPC4 in complex with Calmodulin
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b1g
Q-score: 0.489
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Trpc4 membrane protein in complex with calmodulin (126 kDa, Cellular component)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Transient receptor potential cation channel subfamily c member 4a (Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (Cellular component from Mus musculus)
Structure of the Lifeact-F-actin complex
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ad9
Q-score: 0.466
Belyy A, Merino F, Sitsel O, Raunser S
PLoS Biol (2020) 18 pp. e3000925-e3000925 [ Pubmed: 33216759 DOI: doi:10.1371/journal.pbio.3000925 ]
- Actin (Complex from Oryctolagus cuniculus)
- Magnesium ion (24 Da, Ligand)
- Actin, alpha skeletal muscle (42 kDa, Protein from Rabbit)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phalloidin (808 Da, Protein from synthetic construct)
- Phalloidin (Complex from synthetic construct)
- Complex between skeletal actin from rabbit, phalloidin and lifeact (163 MDa, Complex)
- Lifeact (Complex from Saccharomyces cerevisiae)
- Lifeact (1 kDa, Protein from Saccharomyces cerevisiae)
- Phosphate ion (94 Da, Ligand)
Morganella morganii TcdA4 in complex with porcine mucosa heparin
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6yew
Q-score: 0.478
Roderer D, Brocker F, Sitsel O, Kaplonek P, Leidreiter F, Seeberger PH, Raunser S
Nat Commun (2020) 11 pp. 2694-2694 [ Pubmed: 32483155 DOI: doi:10.1038/s41467-020-16536-7 ]