Thin filament from FIB milled relaxed left ventricular mouse myofibrils
Resolution: 8.0 Å
EM Method: Subtomogram averaging
Fitted PDBs: 8q4g
Q-score: 0.129
Resolution: 18.0 Å
EM Method: Subtomogram averaging
Fitted PDBs: 8q6t
Q-score: 0.055
Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin M, Grange M, Kho AL, Rees M, Bennett P, Gautel M, Raunser S
Nature (2023) 623 pp. 863-871 [ DOI: doi:10.1038/s41586-023-06690-5 Pubmed: 37914933 ]
- Relaxed thick filament; a-band region; c-type super-repeat (Cell from Mus musculus)
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (18 kDa, Protein from Mus musculus)
- Myosin binding protein c, cardiac (44 kDa, Protein from Mus musculus)
- Titin (118 kDa, Protein from Mus musculus)
- Myosin-7 (223 kDa, Protein from Mus musculus)
- Myosin light chain 3 (17 kDa, Protein from Mus musculus)
TRPC4 in complex with inhibitor GFB-8749
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7b05
Q-score: 0.476
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-8749 (108 kDa, Complex from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
- 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{h}-pyridazin-6-one (360 Da, Ligand)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7b0j
Q-score: 0.581
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60603 Pubmed: 33236980 ]
- Trpc4 membrane protein (108 kDa, Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
TRPC4 in complex with inhibitor GFB-8438
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b0s
Q-score: 0.501
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Trpc4 in complex with inhibitor gfb-8438 (108 kDa, Cellular component from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- 5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{h}-pyridazin-6-one (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
TRPC4 in complex with inhibitor GFB-9289
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7b16
Q-score: 0.563
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- 5-chloranyl-4-(4-cyclohexyl-3-oxidanylidene-piperazin-1-yl)-1~{h}-pyridazin-6-one (310 Da, Ligand)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-9289 (108 kDa, Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
TRPC4 in complex with Calmodulin
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b1g
Q-score: 0.489
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ Pubmed: 33236980 DOI: doi:10.7554/eLife.60603 ]
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Trpc4 membrane protein in complex with calmodulin (126 kDa, Cellular component)
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- Transient receptor potential cation channel subfamily c member 4a (Cellular component from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Calcium ion (40 Da, Ligand)
- Calmodulin-1 (Cellular component from Mus musculus)
CryoEM structure and molecular model of squid hemocyanin (Todarodes pacificus , TpH)
Resolution: 5.1 Å
EM Method: Single-particle
Fitted PDBs: 6r83
Q-score: 0.23
Tanaka Y, Kato S, Stabrin M, Raunser S, Matsui T, Gatsogiannis C
IUCrJ (2019) 6 pp. 426-437 [ DOI: doi:10.1107/S205225251900321X Pubmed: 31098023 ]
- Squid hemocyanin (3 MDa, Complex from Todarodes pacificus)
- Hemocyanin subunit 1 (379 kDa, Protein from Todarodes pacificus)